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Pharmacology

Cefepime Pharmacokinetics in Critically Ill Pediatric Patients Receiving Continuous Renal Replacement Therapy

Gideon Stitt, Jennifer Morris, Lindsay Schmees, Joseph Angelo, Ayse Akcan Arikan
Gideon Stitt
aDepartment of Pharmacy Services, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
bDepartment of Pharmacy Services, Texas Children’s Hospital, Houston, Texas, USA
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Jennifer Morris
bDepartment of Pharmacy Services, Texas Children’s Hospital, Houston, Texas, USA
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Lindsay Schmees
bDepartment of Pharmacy Services, Texas Children’s Hospital, Houston, Texas, USA
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Joseph Angelo
cDepartment of Pediatrics, Renal Section, Baylor College of Medicine, Houston, Texas, USA
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Ayse Akcan Arikan
cDepartment of Pediatrics, Renal Section, Baylor College of Medicine, Houston, Texas, USA
dDepartment of Pediatrics, Section of Critical Care Medicine, Baylor College of Medicine, Houston, Texas, USA
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DOI: 10.1128/AAC.02006-18
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ABSTRACT

This retrospective study included pediatric intensive care unit patients receiving continuous veno-venous hemodiafiltration (CVVHDF) being treated with cefepime. The free drug concentration above one time the MIC (fT>1×MIC) and four times a presumed MIC (fT>4×MIC) of 8 μg/ml were calculated. Four patients received doses ranging from 48 to 64 mg/kg of body weight every 6 to 12 h. Three patients achieved 100% fT>1×MIC, with the fourth patient achieving 98% fT>1×MIC. Therapeutic drug monitoring should be considered for critically ill patients receiving cefepime on CVVHDF.

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Cefepime Pharmacokinetics in Critically Ill Pediatric Patients Receiving Continuous Renal Replacement Therapy
Gideon Stitt, Jennifer Morris, Lindsay Schmees, Joseph Angelo, Ayse Akcan Arikan
Antimicrobial Agents and Chemotherapy Mar 2019, 63 (4) e02006-18; DOI: 10.1128/AAC.02006-18

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Cefepime Pharmacokinetics in Critically Ill Pediatric Patients Receiving Continuous Renal Replacement Therapy
Gideon Stitt, Jennifer Morris, Lindsay Schmees, Joseph Angelo, Ayse Akcan Arikan
Antimicrobial Agents and Chemotherapy Mar 2019, 63 (4) e02006-18; DOI: 10.1128/AAC.02006-18
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KEYWORDS

intensive care units
pediatrics
pharmacodynamics
pharmacokinetics
renal replacement therapy

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