Article Figures & Data
Tables
- TABLE 1
Patient demographics
Characteristic Data by patient 1 2 3 4 Age (yr) 1.1 0.6 0.5 5 Sex Male Female Male Male Hospital admission diagnosis Liver transplant Liver failure Hyponatremia HLHa Estimated dry wt (kg) 10 6 5.4 25 Body surface area (m2) 0.45 0.33 0.33 0.94 Baseline SCr (mg/dl)b 0.14 Unknownc 0.15 0.3 SCr at CRRT initiation (mg/dl) 0.41 0.53 0.59 3.37 Mean urine output at CRRT initiation (ml/kg/h)d 1.3 1.6 1.4 0.25 Mean urine output at sampling (ml/kg/h)e 0.22 0.64 0.07 0 Cefepime dose (mg/kg)f 48 57 55 64 Dosing interval (h) 8 8 6 12 Infusion time (h) 3 0.5 0.5 0.5 No. of samples collected 3 2 3 3 No. of doses received prior to first sample 18 3 7 2 - TABLE 2
CVVHDF parameters
Parameter Data by patient 1 2 3 4 Dialysate (ml/h) 1,500 1,000 550 650 Pre-filter replacement (ml/h) 500 450 500 600 Post-filter replacement (ml/h) 50 50 50 50 Blood flow (ml/min) 90 40 70 100 Blood flow (ml/kg/min) 9 6.7 13 4 Normalized effluent rate (ml/1.73 m2/h) 8,750 8,593 6,089 3,076 Effluent urea/BUN ratioa 0.75 0.75 0.75 0.77 Delivered CVVHDF clearance (ml/1.73 m2/h)b 6,563 6,445 4,567 2,369 Circuit age (h)c 22.6 33.8 15.2 11.2 - TABLE 3
Calculated PK and PD parameters
Parameter Data by patient 1 2 3 4 ke (h−1) 0.24 0.44 0.67 0.31 T1/2 (h)a 2.9 1.6 1 2.2 Vd (liters/kg) 0.23 0.17 0.12 0.04 Cl (liters/h/kg) 0.055 0.075 0.08 0.012 Calculated free Cmax (μg/ml)b 138.6 244.8 306.4 1,268.2 Calculated free Cmin (μg/ml)c 22.7 9.1 7.7 38.6 %fT>1×MICd 100 100 98.3 100 %fT>4×MICd 82.3 63.8 65 100