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Experimental Therapeutics

Synergistic Antifungal Effect of Amphotericin B-Loaded Poly(Lactic-Co-Glycolic Acid) Nanoparticles and Ultrasound against Candida albicans Biofilms

Min Yang, Kaiyue Du, Yuru Hou, Shuang Xie, Yu Dong, Dairong Li, Yonghong Du
Min Yang
aState Key Laboratory of Ultrasound Engineering in Medicine Co-founded by Chongqing and the Ministry of Science and Technology, Chongqing Collaborative Innovation Center for Minimally Invasive and Noninvasive Medicine, College of Biomedical Engineering, Chongqing Medical University, Chongqing, China
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Kaiyue Du
bPeking University School of Basic Medical Sciences, Beijing, China
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Yuru Hou
aState Key Laboratory of Ultrasound Engineering in Medicine Co-founded by Chongqing and the Ministry of Science and Technology, Chongqing Collaborative Innovation Center for Minimally Invasive and Noninvasive Medicine, College of Biomedical Engineering, Chongqing Medical University, Chongqing, China
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Shuang Xie
aState Key Laboratory of Ultrasound Engineering in Medicine Co-founded by Chongqing and the Ministry of Science and Technology, Chongqing Collaborative Innovation Center for Minimally Invasive and Noninvasive Medicine, College of Biomedical Engineering, Chongqing Medical University, Chongqing, China
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Yu Dong
aState Key Laboratory of Ultrasound Engineering in Medicine Co-founded by Chongqing and the Ministry of Science and Technology, Chongqing Collaborative Innovation Center for Minimally Invasive and Noninvasive Medicine, College of Biomedical Engineering, Chongqing Medical University, Chongqing, China
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Dairong Li
cDepartment of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Yonghong Du
aState Key Laboratory of Ultrasound Engineering in Medicine Co-founded by Chongqing and the Ministry of Science and Technology, Chongqing Collaborative Innovation Center for Minimally Invasive and Noninvasive Medicine, College of Biomedical Engineering, Chongqing Medical University, Chongqing, China
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DOI: 10.1128/AAC.02022-18
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Article Information

DOI 
https://doi.org/10.1128/AAC.02022-18
PubMed 
30670414

Published By 
American Society for Microbiology Journals
History 
  • Received September 20, 2018
  • Returned for modification November 24, 2018
  • Accepted January 13, 2019
  • Published online March 27, 2019.

Copyright & Usage 
Copyright © 2019 American Society for Microbiology. All Rights Reserved.

Article Versions

  • Accepted Manuscript version (January 22, 2019).
  • You are viewing the most recent version of this article.

Author Information

  1. Min Yanga,
  2. Kaiyue Dub,
  3. Yuru Houa,
  4. Shuang Xiea,
  5. Yu Donga,
  6. Dairong Lic and
  7. Yonghong Dua
  1. aState Key Laboratory of Ultrasound Engineering in Medicine Co-founded by Chongqing and the Ministry of Science and Technology, Chongqing Collaborative Innovation Center for Minimally Invasive and Noninvasive Medicine, College of Biomedical Engineering, Chongqing Medical University, Chongqing, China
  2. bPeking University School of Basic Medical Sciences, Beijing, China
  3. cDepartment of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China
  • Address correspondence to Dairong Li, lidairong-e{at}yeah.net, or Yonghong Du, duyonghong_e{at}126.com.
  • Citation Yang M, Du K, Hou Y, Xie S, Dong Y, Li D, Du Y. 2019. Synergistic antifungal effect of amphotericin B-loaded poly(lactic-co-glycolic acid) nanoparticles and ultrasound against Candida albicans biofilms. Antimicrob Agents Chemother 63:e02022-18. https://doi.org/10.1128/AAC.02022-18.

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Synergistic Antifungal Effect of Amphotericin B-Loaded Poly(Lactic-Co-Glycolic Acid) Nanoparticles and Ultrasound against Candida albicans Biofilms
Min Yang, Kaiyue Du, Yuru Hou, Shuang Xie, Yu Dong, Dairong Li, Yonghong Du
Antimicrobial Agents and Chemotherapy Mar 2019, 63 (4) e02022-18; DOI: 10.1128/AAC.02022-18

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Synergistic Antifungal Effect of Amphotericin B-Loaded Poly(Lactic-Co-Glycolic Acid) Nanoparticles and Ultrasound against Candida albicans Biofilms
Min Yang, Kaiyue Du, Yuru Hou, Shuang Xie, Yu Dong, Dairong Li, Yonghong Du
Antimicrobial Agents and Chemotherapy Mar 2019, 63 (4) e02022-18; DOI: 10.1128/AAC.02022-18
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KEYWORDS

amphotericin B
C. albicans biofilm
PLGA nanoparticles
synergistic antifungal
ultrasound

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