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Experimental Therapeutics

In Vitro and In Vivo Activities of the Riminophenazine TBI-166 against Mycobacterium tuberculosis

Jian Xu, Bin Wang, Lei Fu, Hui Zhu, Shaochen Guo, Haihong Huang, Dali Yin, Ye Zhang, Yu Lu
Jian Xu
aBeijing Key Laboratory of Drug Resistance Tuberculosis Research, Beijing Tuberculosis and Thoracic Tumor Research Institute, and Beijing Chest Hospital, Capital Medical University, Beijing, China
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Bin Wang
aBeijing Key Laboratory of Drug Resistance Tuberculosis Research, Beijing Tuberculosis and Thoracic Tumor Research Institute, and Beijing Chest Hospital, Capital Medical University, Beijing, China
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Lei Fu
aBeijing Key Laboratory of Drug Resistance Tuberculosis Research, Beijing Tuberculosis and Thoracic Tumor Research Institute, and Beijing Chest Hospital, Capital Medical University, Beijing, China
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Hui Zhu
aBeijing Key Laboratory of Drug Resistance Tuberculosis Research, Beijing Tuberculosis and Thoracic Tumor Research Institute, and Beijing Chest Hospital, Capital Medical University, Beijing, China
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Shaochen Guo
aBeijing Key Laboratory of Drug Resistance Tuberculosis Research, Beijing Tuberculosis and Thoracic Tumor Research Institute, and Beijing Chest Hospital, Capital Medical University, Beijing, China
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Haihong Huang
bBeijing Key Laboratory of Active Substance Discovery and Druggability Evaluation, Institute of Materia Medica, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China
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Dali Yin
bBeijing Key Laboratory of Active Substance Discovery and Druggability Evaluation, Institute of Materia Medica, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China
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Ye Zhang
aBeijing Key Laboratory of Drug Resistance Tuberculosis Research, Beijing Tuberculosis and Thoracic Tumor Research Institute, and Beijing Chest Hospital, Capital Medical University, Beijing, China
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Yu Lu
aBeijing Key Laboratory of Drug Resistance Tuberculosis Research, Beijing Tuberculosis and Thoracic Tumor Research Institute, and Beijing Chest Hospital, Capital Medical University, Beijing, China
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DOI: 10.1128/AAC.02155-18
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Article Information

DOI 
https://doi.org/10.1128/AAC.02155-18
PubMed 
30782992

Published By 
American Society for Microbiology Journals
History 
  • Received October 11, 2018
  • Returned for modification December 20, 2018
  • Accepted February 1, 2019
  • Published online April 25, 2019.

Copyright & Usage 
Copyright © 2019 American Society for Microbiology. All Rights Reserved.

Article Versions

  • Accepted Manuscript version (February 19, 2019).
  • You are viewing the most recent version of this article.

Author Information

  1. Jian Xua,
  2. Bin Wanga,
  3. Lei Fua,
  4. Hui Zhua,
  5. Shaochen Guoa,
  6. Haihong Huangb,
  7. Dali Yinb,
  8. Ye Zhanga and
  9. Yu Lua
  1. aBeijing Key Laboratory of Drug Resistance Tuberculosis Research, Beijing Tuberculosis and Thoracic Tumor Research Institute, and Beijing Chest Hospital, Capital Medical University, Beijing, China
  2. bBeijing Key Laboratory of Active Substance Discovery and Druggability Evaluation, Institute of Materia Medica, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China
  • Address correspondence to Yu Lu, luyu4876{at}hotmail.com.
  • J.X. and B.W. contributed equally to the work.

  • Citation Xu J, Wang B, Fu L, Zhu H, Guo S, Huang H, Yin D, Zhang Y, Lu Y. 2019. In vitro and in vivo activities of the riminophenazine TBI-166 against Mycobacterium tuberculosis. Antimicrob Agents Chemother 63:e02155-18. https://doi.org/10.1128/AAC.02155-18.

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In Vitro and In Vivo Activities of the Riminophenazine TBI-166 against Mycobacterium tuberculosis
Jian Xu, Bin Wang, Lei Fu, Hui Zhu, Shaochen Guo, Haihong Huang, Dali Yin, Ye Zhang, Yu Lu
Antimicrobial Agents and Chemotherapy Apr 2019, 63 (5) e02155-18; DOI: 10.1128/AAC.02155-18

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In Vitro and In Vivo Activities of the Riminophenazine TBI-166 against Mycobacterium tuberculosis
Jian Xu, Bin Wang, Lei Fu, Hui Zhu, Shaochen Guo, Haihong Huang, Dali Yin, Ye Zhang, Yu Lu
Antimicrobial Agents and Chemotherapy Apr 2019, 63 (5) e02155-18; DOI: 10.1128/AAC.02155-18
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KEYWORDS

riminophenazine
TBI-166
clofazimine
in vivo
Mycobacterium tuberculosis

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