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Editor's Pick Pharmacology

Fluoroquinolone Efficacy against Tuberculosis Is Driven by Penetration into Lesions and Activity against Resident Bacterial Populations

Jansy Sarathy, Landry Blanc, Nadine Alvarez-Cabrera, Paul O’Brien, Isabela Dias-Freedman, Marizel Mina, Matthew Zimmerman, Firat Kaya, Hsin-Pin Ho Liang, Brendan Prideaux, Jillian Dietzold, Padmini Salgame, Radojka M. Savic, Jennifer Linderman, Denise Kirschner, Elsje Pienaar, Véronique Dartois
Jansy Sarathy
aPublic Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, New Jersey, USA
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Landry Blanc
aPublic Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, New Jersey, USA
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Nadine Alvarez-Cabrera
aPublic Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, New Jersey, USA
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Paul O’Brien
aPublic Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, New Jersey, USA
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Isabela Dias-Freedman
aPublic Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, New Jersey, USA
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Marizel Mina
aPublic Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, New Jersey, USA
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Matthew Zimmerman
aPublic Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, New Jersey, USA
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Firat Kaya
aPublic Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, New Jersey, USA
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Hsin-Pin Ho Liang
aPublic Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, New Jersey, USA
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Brendan Prideaux
aPublic Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, New Jersey, USA
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Jillian Dietzold
bDepartment of Medicine, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, New Jersey, USA
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Padmini Salgame
bDepartment of Medicine, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, New Jersey, USA
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Radojka M. Savic
cDepartment of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, USA
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Jennifer Linderman
dDepartment of Chemical Engineering, University of Michigan, Ann Arbor, Michigan, USA
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Denise Kirschner
eDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA
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Elsje Pienaar
dDepartment of Chemical Engineering, University of Michigan, Ann Arbor, Michigan, USA
eDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA
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Véronique Dartois
aPublic Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, New Jersey, USA
bDepartment of Medicine, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, New Jersey, USA
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DOI: 10.1128/AAC.02516-18
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Article Information

DOI 
https://doi.org/10.1128/AAC.02516-18
PubMed 
30803965

Published By 
American Society for Microbiology Journals
History 
  • Received November 30, 2018
  • Returned for modification January 21, 2019
  • Accepted February 17, 2019
  • Published online April 25, 2019.

Copyright & Usage 
Copyright © 2019 Sarathy et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

Article Versions

  • Accepted Manuscript version (February 25, 2019).
  • You are viewing the most recent version of this article.

Author Information

  1. Jansy Sarathya,
  2. Landry Blanca,
  3. Nadine Alvarez-Cabreraa,
  4. Paul O’Briena,
  5. Isabela Dias-Freedmana,
  6. Marizel Minaa,
  7. Matthew Zimmermana,
  8. Firat Kayaa,
  9. Hsin-Pin Ho Lianga,
  10. Brendan Prideauxa,
  11. Jillian Dietzoldb,
  12. Padmini Salgameb,
  13. Radojka M. Savicc,
  14. Jennifer Lindermand,
  15. Denise Kirschnere,
  16. Elsje Pienaard,e* and
  17. Véronique Dartoisa,b
  1. aPublic Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, New Jersey, USA
  2. bDepartment of Medicine, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, New Jersey, USA
  3. cDepartment of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, USA
  4. dDepartment of Chemical Engineering, University of Michigan, Ann Arbor, Michigan, USA
  5. eDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA
  • Address correspondence to Véronique Dartois, veronique.dartois{at}rutgers.edu.
  • ↵* Present address: Elsje Pienaar, Purdue University, Weldon School of Biomedical Engineering, West Lafayette, Indiana, USA.

  • J.S. and L.B. contributed equally to the present article.

  • Citation Sarathy J, Blanc L, Alvarez-Cabrera N, O’Brien P, Dias-Freedman I, Mina M, Zimmerman M, Kaya F, Ho Liang H-P, Prideaux B, Dietzold J, Salgame P, Savic RM, Linderman J, Kirschner D, Pienaar E, Dartois V. 2019. Fluoroquinolone efficacy against tuberculosis is driven by penetration into lesions and activity against resident bacterial populations. Antimicrob Agents Chemother 63:e02516-18. https://doi.org/10.1128/AAC.02516-18.

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Fluoroquinolone Efficacy against Tuberculosis Is Driven by Penetration into Lesions and Activity against Resident Bacterial Populations
Jansy Sarathy, Landry Blanc, Nadine Alvarez-Cabrera, Paul O’Brien, Isabela Dias-Freedman, Marizel Mina, Matthew Zimmerman, Firat Kaya, Hsin-Pin Ho Liang, Brendan Prideaux, Jillian Dietzold, Padmini Salgame, Radojka M. Savic, Jennifer Linderman, Denise Kirschner, Elsje Pienaar, Véronique Dartois
Antimicrobial Agents and Chemotherapy Apr 2019, 63 (5) e02516-18; DOI: 10.1128/AAC.02516-18

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Fluoroquinolone Efficacy against Tuberculosis Is Driven by Penetration into Lesions and Activity against Resident Bacterial Populations
Jansy Sarathy, Landry Blanc, Nadine Alvarez-Cabrera, Paul O’Brien, Isabela Dias-Freedman, Marizel Mina, Matthew Zimmerman, Firat Kaya, Hsin-Pin Ho Liang, Brendan Prideaux, Jillian Dietzold, Padmini Salgame, Radojka M. Savic, Jennifer Linderman, Denise Kirschner, Elsje Pienaar, Véronique Dartois
Antimicrobial Agents and Chemotherapy Apr 2019, 63 (5) e02516-18; DOI: 10.1128/AAC.02516-18
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KEYWORDS

MDR-TB
fluoroquinolone
lesion-centric pharmacology
moxifloxacin
tuberculosis

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