Skip to main content
  • ASM
    • Antimicrobial Agents and Chemotherapy
    • Applied and Environmental Microbiology
    • Clinical Microbiology Reviews
    • Clinical and Vaccine Immunology
    • EcoSal Plus
    • Eukaryotic Cell
    • Infection and Immunity
    • Journal of Bacteriology
    • Journal of Clinical Microbiology
    • Journal of Microbiology & Biology Education
    • Journal of Virology
    • mBio
    • Microbiology and Molecular Biology Reviews
    • Microbiology Resource Announcements
    • Microbiology Spectrum
    • Molecular and Cellular Biology
    • mSphere
    • mSystems
  • Log in
  • My alerts
  • My Cart

Main menu

  • Home
  • Articles
    • Current Issue
    • Accepted Manuscripts
    • COVID-19 Special Collection
    • Archive
    • Minireviews
  • For Authors
    • Submit a Manuscript
    • Scope
    • Editorial Policy
    • Submission, Review, & Publication Processes
    • Organization and Format
    • Errata, Author Corrections, Retractions
    • Illustrations and Tables
    • Nomenclature
    • Abbreviations and Conventions
    • Publication Fees
    • Ethics Resources and Policies
  • About the Journal
    • About AAC
    • Editor in Chief
    • Editorial Board
    • For Reviewers
    • For the Media
    • For Librarians
    • For Advertisers
    • Alerts
    • AAC Podcast
    • RSS
    • FAQ
  • Subscribe
    • Members
    • Institutions
  • ASM
    • Antimicrobial Agents and Chemotherapy
    • Applied and Environmental Microbiology
    • Clinical Microbiology Reviews
    • Clinical and Vaccine Immunology
    • EcoSal Plus
    • Eukaryotic Cell
    • Infection and Immunity
    • Journal of Bacteriology
    • Journal of Clinical Microbiology
    • Journal of Microbiology & Biology Education
    • Journal of Virology
    • mBio
    • Microbiology and Molecular Biology Reviews
    • Microbiology Resource Announcements
    • Microbiology Spectrum
    • Molecular and Cellular Biology
    • mSphere
    • mSystems

User menu

  • Log in
  • My alerts
  • My Cart

Search

  • Advanced search
Antimicrobial Agents and Chemotherapy
publisher-logosite-logo

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Accepted Manuscripts
    • COVID-19 Special Collection
    • Archive
    • Minireviews
  • For Authors
    • Submit a Manuscript
    • Scope
    • Editorial Policy
    • Submission, Review, & Publication Processes
    • Organization and Format
    • Errata, Author Corrections, Retractions
    • Illustrations and Tables
    • Nomenclature
    • Abbreviations and Conventions
    • Publication Fees
    • Ethics Resources and Policies
  • About the Journal
    • About AAC
    • Editor in Chief
    • Editorial Board
    • For Reviewers
    • For the Media
    • For Librarians
    • For Advertisers
    • Alerts
    • AAC Podcast
    • RSS
    • FAQ
  • Subscribe
    • Members
    • Institutions
Pharmacology

Comparative Performance of Urinary Biomarkers for Vancomycin-Induced Kidney Injury According to Timeline of Injury

Gwendolyn M. Pais, Sean N. Avedissian, J. Nicholas O’Donnell, Nathaniel J. Rhodes, Thomas P. Lodise, Walter C. Prozialeck, Peter C. Lamar, Cameron Cluff, Anil Gulati, Julie C. Fitzgerald, Kevin J. Downes, Athena F. Zuppa, Marc H. Scheetz
Gwendolyn M. Pais
aDepartment of Pharmacy Practice, Chicago College of Pharmacy, Midwestern University, Downers Grove, Illinois, USA
bPharmacometrics Center of Excellence, Chicago College of Pharmacy, Midwestern University, Downers Grove, Illinois, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sean N. Avedissian
aDepartment of Pharmacy Practice, Chicago College of Pharmacy, Midwestern University, Downers Grove, Illinois, USA
bPharmacometrics Center of Excellence, Chicago College of Pharmacy, Midwestern University, Downers Grove, Illinois, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
J. Nicholas O’Donnell
cDepartment of Pharmacy Practice, Albany College of Pharmacy and Health Sciences, Albany, New York, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for J. Nicholas O’Donnell
Nathaniel J. Rhodes
aDepartment of Pharmacy Practice, Chicago College of Pharmacy, Midwestern University, Downers Grove, Illinois, USA
bPharmacometrics Center of Excellence, Chicago College of Pharmacy, Midwestern University, Downers Grove, Illinois, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Nathaniel J. Rhodes
Thomas P. Lodise
cDepartment of Pharmacy Practice, Albany College of Pharmacy and Health Sciences, Albany, New York, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Walter C. Prozialeck
dDepartment of Pharmacology, College of Graduate Studies, Midwestern University, Downers Grove, Illinois, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Peter C. Lamar
dDepartment of Pharmacology, College of Graduate Studies, Midwestern University, Downers Grove, Illinois, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Cameron Cluff
aDepartment of Pharmacy Practice, Chicago College of Pharmacy, Midwestern University, Downers Grove, Illinois, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Anil Gulati
eDepartment of Pharmaceutical Sciences, Chicago College of Pharmacy, Midwestern University, Downers Grove, Illinois, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Julie C. Fitzgerald
fDivision of Critical Care, Department of Anesthesiology and Critical Care, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kevin J. Downes
gDivision of Infectious Diseases, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
hDepartment of Pediatrics, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Athena F. Zuppa
fDivision of Critical Care, Department of Anesthesiology and Critical Care, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Marc H. Scheetz
aDepartment of Pharmacy Practice, Chicago College of Pharmacy, Midwestern University, Downers Grove, Illinois, USA
bPharmacometrics Center of Excellence, Chicago College of Pharmacy, Midwestern University, Downers Grove, Illinois, USA
dDepartment of Pharmacology, College of Graduate Studies, Midwestern University, Downers Grove, Illinois, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Marc H. Scheetz
DOI: 10.1128/AAC.00079-19
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

Article Figures & Data

Figures

  • Tables
  • Additional Files
  • FIG 1
    • Open in new tab
    • Download powerpoint
    FIG 1

    (a) Flow chart for animal dosing. TDD, total daily dose; q12h, every 12 h; *, missed second dose on day 6. (b) Timeline of the experiments.

  • FIG 2
    • Open in new tab
    • Download powerpoint
    FIG 2

    Representative photomicrographs of hematoxylin and eosin (H&E) stained rat kidney sections. (a and d) Normal histology of kidney tissue in control rats administered normal saline intraperitoneally once daily for 24 h (×40) and 72 h (×200), respectively. (b) Classic wedge-shaped region of infarct (asterisk, ×20) with (c) necrosis of tubular epithelium and portions of glomeruli (arrowheads, ×100) in cortex of rats treated with vancomycin 200 mg/kg once daily for 24 h. (e) Multiple tubules containing sloughed cells (arrowheads) in cortex of rats treated with vancomycin 400 mg/kg once daily for 72 h (×100).

  • FIG 3
    • Open in new tab
    • Download powerpoint
    FIG 3

    ROC analysis for vancomycin studies. (a to d) ROC curves demonstrating sensitivity and specificity of urinary KIM-1, clusterin, OPN, cystatin C, and NGAL with respect to a histopathology grade of ≥1 on day 1 (a) and on day 3 (b) and a histopathology grade of ≥2 on day 1 (c) and on day 3 (d). Animal numbers, n; histopath = 0, n = 32; histopath ≥ 1, n = 93; histopath ≥ 2, n = 37.

  • FIG 4
    • Open in new tab
    • Download powerpoint
    FIG 4

    Schematic of the nephron (51) and urinary biomarker colocalization with injury (21). Bolded biomarker will aid in discretizing injury location.

Tables

  • Figures
  • Additional Files
  • TABLE 1

    Comparative analysis of diagnostic performance characteristics of urinary biomarkers with different severity grades of histopathology using area under the receiver operating characteristic curvesa

    SubgroupBiomarker (ng/ml)Day 1 biomarkers predicting 24 h histopath (AUC [95% CI])Day 3 biomarkers predicting 72 h histopath (AUC [95% CI])Day 2 biomarkers predicting 144 h histopath (AUC [95% CI])Day 6 biomarkers predicting 144 h histopath (AUC [95% CI])
    Histopath of ≥1NGAL0.320 (0.14–0.50)0.758 (0.61–0.91)0.649 (0.39–0.91)0.760 (0.56–0.96)
    KIM-10.661 (0.50–0.82)0.923 (0.85–1.00)0.752 (0.59–0.91)0.918 (0.82–1.00)
    Clusterin0.706 (0.55–0.86)0.892 (0.80–0.99)0.754 (0.59–0.92)0.889 (0.78–1.00)
    OPN0.590 (0.41–0.77)0.952 (0.90–1.00)0.615 (0.41–0.82)0.757 (0.58–0.94)
    Cystatin C0.483 (0.29–0.68)0.688 (0.49–0.89)0.692 (0.47–0.91)0.538 (0.29–0.78)
    Histopath of ≥2NGAL0.381 (0.16–0.60)0.555 (0.36–0.75)0.668 (0.44–0.90)0.71 (0.53–0.89)
    KIM-10.762 (0.46–1.00)0.822 (0.70–0.95)0.913 (0.79–1.00)0.90 (0.80–1.00)
    Clusterin0.762 (0.52–1.00)0.801 (0.67–0.93)0.861 (0.74–1.00)0.82 (0.68–0.96)
    OPN0.714 (0.46–0.97)0.695 (0.53–0.86)0.828 (0.68–0.98)0.85 (0.72–0.99)
    Cystatin C0.394 (0.14–0.65)0.549 (0.37–0.72)0.695 (0.49–0.90)0.55 (0.34–0.76)
    Histopath of ≥3NGALOutcome does not vary0.571 (0.37–0.77)0.931 (0.84–1.00)0.58 (0.40–0.76)
    KIM-1Outcome does not vary0.476 (0.21–0.74)0.986 (0.95–1.00)0.83 (0.68–0.99)
    ClusterinOutcome does not vary0.381 (0.23–0.53)0.793 (0.63–0.96)0.72 (0.53–0.92)
    OPNOutcome does not vary0.511 (0.18–0.84)0.755 (0.60–0.91)0.69 (0.52–0.86)
    Cystatin COutcome does not vary0.488 (0.00–1.00)0.813 (0.48–1.00)0.37 (0.16–0.57)
    • ↵a AUC, area under the receiver operating characteristic curve; CI, confidence interval; NGAL, neutrophil gelatinase-associated lipocalin; KIM-1, kidney injury molecule-1; OPN, osteopontin.

Additional Files

  • Figures
  • Tables
  • Supplemental material

    • Supplemental file 1 -

      Supplemental material

      PDF, 869K

PreviousNext
Back to top
Download PDF
Citation Tools
Comparative Performance of Urinary Biomarkers for Vancomycin-Induced Kidney Injury According to Timeline of Injury
Gwendolyn M. Pais, Sean N. Avedissian, J. Nicholas O’Donnell, Nathaniel J. Rhodes, Thomas P. Lodise, Walter C. Prozialeck, Peter C. Lamar, Cameron Cluff, Anil Gulati, Julie C. Fitzgerald, Kevin J. Downes, Athena F. Zuppa, Marc H. Scheetz
Antimicrobial Agents and Chemotherapy Jun 2019, 63 (7) e00079-19; DOI: 10.1128/AAC.00079-19

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Print

Alerts
Sign In to Email Alerts with your Email Address
Email

Thank you for sharing this Antimicrobial Agents and Chemotherapy article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Comparative Performance of Urinary Biomarkers for Vancomycin-Induced Kidney Injury According to Timeline of Injury
(Your Name) has forwarded a page to you from Antimicrobial Agents and Chemotherapy
(Your Name) thought you would be interested in this article in Antimicrobial Agents and Chemotherapy.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Comparative Performance of Urinary Biomarkers for Vancomycin-Induced Kidney Injury According to Timeline of Injury
Gwendolyn M. Pais, Sean N. Avedissian, J. Nicholas O’Donnell, Nathaniel J. Rhodes, Thomas P. Lodise, Walter C. Prozialeck, Peter C. Lamar, Cameron Cluff, Anil Gulati, Julie C. Fitzgerald, Kevin J. Downes, Athena F. Zuppa, Marc H. Scheetz
Antimicrobial Agents and Chemotherapy Jun 2019, 63 (7) e00079-19; DOI: 10.1128/AAC.00079-19
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Top
  • Article
    • ABSTRACT
    • TEXT
    • RESULTS
    • DISCUSSION
    • MATERIALS AND METHODS
    • ACKNOWLEDGMENTS
    • FOOTNOTES
    • REFERENCES
  • Figures & Data
  • Info & Metrics
  • PDF

KEYWORDS

KIM-1
PK/PD
PK/TD
biomarker
histopathology
injury
kidney
toxicity
urinary
vancomycin

Related Articles

Cited By...

About

  • About AAC
  • Editor in Chief
  • Editorial Board
  • Policies
  • For Reviewers
  • For the Media
  • For Librarians
  • For Advertisers
  • Alerts
  • AAC Podcast
  • RSS
  • FAQ
  • Permissions
  • Journal Announcements

Authors

  • ASM Author Center
  • Submit a Manuscript
  • Article Types
  • Ethics
  • Contact Us

Follow #AACJournal

@ASMicrobiology

       

ASM Journals

ASM journals are the most prominent publications in the field, delivering up-to-date and authoritative coverage of both basic and clinical microbiology.

About ASM | Contact Us | Press Room

 

ASM is a member of

Scientific Society Publisher Alliance

 

American Society for Microbiology
1752 N St. NW
Washington, DC 20036
Phone: (202) 737-3600

Copyright © 2021 American Society for Microbiology | Privacy Policy | Website feedback

Print ISSN: 0066-4804; Online ISSN: 1098-6596