Article Figures & Data
Tables
- TABLE 1
MIC results for Fusarium species ocular isolatesa
Isolate Antifungal MIC (μg/ml) Nonantifungal MIC (μg/ml) NAT VOR 5FU DRZ EDTA TIM F. solani 132.02 16 16 1,880 >5,575 403 >6,800 06-0487 26 >128 3,750 >5,575 819 >6,800 06-0330 26 >128 2,500 >5,575 2,041 >6,800 06-0133 29 >128 2,500 >5,575 819 >6,800 06-0111 32 >128 2,500 >5,575 1,222 >6,800 06-0110 29 >128 2,500 >5,575 2,041 >6,800 F. oxysporum 06-0342 26 >128 5,000 >5,575 2,041 >6,800 06-0197 14 4 3,750 >5,575 1,222 >6,800 ↵a NAT, natamycin; VOR, voriconazole; 5FU, 5-fluorouracil; DRZ, dorzolamide; TIM, timolol.
- TABLE 2
FICI results for Fusarium species ocular isolates
Isolate FICIa Natamycin plus: Voriconazole plus: 5FU DRZ EDTA TIM 5FU DRZ EDTA TIM F. solani 132.02 0.61 0.75 1.00 0.52 0.72 2.00 1.00 0.94 06-0487 0.56 0.75 0.67 0.45 0.75 2.00 0.38 0.53 06-0330 0.40 0.64 0.66 0.41 0.59 2.00 0.63 0.69 06-0133 0.34 0.69 0.75 0.41 0.53 2.00 0.52 0.58 06-0111 0.44 1.00 0.38 0.52 0.59 2.00 0.53 0.66 06-0110 0.40 0.53 0.47 0.41 0.69 2.00 0.52 0.66 F. oxysporum 06-0342 0.40 0.63 0.52 0.41 0.63 2.00 0.45 0.39 06-0197 0.55 0.53 0.56 0.44 0.58 2.00 0.55 0.94 ↵a 5FU, 5-fluorouracil; DRZ, dorzolamide; TIM, timolol. Bold values indicate that the FICI is in the synergistic range (<0.5).
- TABLE 3
MICs for the synergistically interacting antifungal and nonantifungal ophthalmic agents natamycin and timolol
Strain MIC (μg/ml) of each agent alone MIC (μg/ml) of each agent in the combination FICI Avg FICI Natamycin Timolol Natamycin Timolol F. solani 132.02 16 >6,800 8 425 0.53 0.52 4 3,400 0.50 06-0487 32 >6,800 16 213 0.52 0.45 8 1,700 0.38 06-0330 32 >6,800 16 213 0.50 0.41 8 850 0.31 06-0133 32 >6,800 16 53 0.50 0.41 8 850 0.31 06-0111 32 >6,800 16 213 0.52 0.52 06-0110 32 >6,800 16 53 0.50 0.41 8 850 0.31 F. oxysporum 06-0342 32 >6,800 16 213 0.52 0.41 8 850 0.31 06-0197 16 >6,800 8 53 0.50 0.44 4 1,700 0.38 - TABLE 4
MICs for the synergistically interacting antifungal and nonantifungal ophthalmic agents natamycin and 5-fluorouracil
Strain MIC (μg/ml) of each agent alone MIC (μg/ml) of each agent in the combination FICI Avg FICI Natamycin 5-Fluorouracil Natamycin 5-Fluorouracil F. solani 132.02 16 1,250 8 78 0.56 0.59 2 625 0.63 06-0487 16 2,500 8 156 0.56 0.56 4 625 0.50 2 1,250 0.63 06-0330 32 2,500 16 10 0.50 0.40 8 156 0.31 4 625 0.38 06-0133 32 2,500 16 10 0.50 0.34 8 78 0.28 4 313 0.25 2 625 0.31 06-0111 32 2,500 16 10 0.50 0.44 8 156 0.31 4 625 0.38 2 1,250 0.56 06-0110 32 2,500 16 10 0.50 0.40 8 156 0.31 4 625 0.38 F. oxysporum 06-0342 32 5,000 16 78 0.52 0.40 8 313 0.31 4 1,250 0.38 06-0197 16 5,000 8 156 0.53 0.55 4 1,250 0.50 2 2,500 0.63