DOI: 10.1128/AAC.00346-19
ABSTRACT
Surgical site infections (SSIs) are commonly caused by Staphylococcus aureus. We report that a combination of three monoclonal antibodies (MEDI6389) that neutralize S. aureus alpha-toxin, clumping factor A, and four leukocidins (LukSF, LukED, HlgAB, and HlgCB) plus vancomycin had enhanced efficacy compared with control antibody plus vancomycin in two mouse models of S. aureus SSI. Therefore, monoclonal antibody-based neutralization of multiple S. aureus virulence factors may provide an adjunctive perioperative approach to combat S. aureus SSIs.
FOOTNOTES
- Received 27 February 2019.
- Returned for modification 16 April 2019.
- Accepted 19 May 2019.
- Accepted manuscript posted online 28 May 2019.
Supplemental material for this article may be found at https://doi.org/10.1128/AAC.00346-19.
- Copyright © 2019 American Society for Microbiology.
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