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Susceptibility

A Revised Species Concept for Opportunistic Mucor Species Reveals Species-Specific Antifungal Susceptibility Profiles

Lysett Wagner, Sybren de Hoog, Ana Alastruey-Izquierdo, Kerstin Voigt, Oliver Kurzai, Grit Walther
Lysett Wagner
aGerman National Reference Center for Invasive Fungal Infections, Leibniz Institute for Natural Product Research and Infection Biology—Hans Knöll Institute, Jena, Germany
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Sybren de Hoog
bWesterdijk Fungal Biodiversity Institute, Utrecht, The Netherlands
cCenter of Expertise in Mycology of Radboud University Medical Center/Canisius Wilhelmina Hospital, Nijmegen, The Netherlands
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Ana Alastruey-Izquierdo
dMycology Reference Laboratory, National Centre for Microbiology, Instituto de Salud Carlos III, Madrid, Spain
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  • ORCID record for Ana Alastruey-Izquierdo
Kerstin Voigt
eJena Microbial Resource Collection, Leibniz Institute for Natural Product Research and Infection Biology—Hans Knöll Institute, Jena, Germany
fFaculty of Biology and Pharmacy, Institute of Microbiology, Department of Microbiology and Molecular Biology, Friedrich Schiller University Jena, Jena, Germany
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Oliver Kurzai
aGerman National Reference Center for Invasive Fungal Infections, Leibniz Institute for Natural Product Research and Infection Biology—Hans Knöll Institute, Jena, Germany
gInstitute for Hygiene and Microbiology, University of Würzburg, Würzburg, Germany
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Grit Walther
aGerman National Reference Center for Invasive Fungal Infections, Leibniz Institute for Natural Product Research and Infection Biology—Hans Knöll Institute, Jena, Germany
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DOI: 10.1128/AAC.00653-19
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  • TABLE 1

    Ranges of antifungal susceptibilities, geometric means, and MIC50s of the species studied

    Group (no. of isolates)MIC (mg/liter)a
    AMBNATTRBISAITCPOS
    C. recurvatus (3)
        GMb0.032.040.35.03.23.2
        MIC50NAcNANANANANA
        Range≤0.03216–322–80.125–80.125–8
    M. amphibiorum (3)
        GM0.031.620.216.00.10.04
        MIC50NANANANANANA
        Range≤0.031–28–32>80.06–0.50.016–0.125
    M. ardhlaengiktus (2)
        GM0.042.86416.016.016.0
        MIC50NANANANANANA
        Range≤0.03–0.062–4>32>8>8>8
    M. circinelloides (14)
        GM0.11.9645.13.10.6
        MIC500.1252>32440.5
        Range≤0.03–0.51–4>322–80.5–80.125–4
    M. griseocyanus (4)
        GM0.12.0646.72.80.6
        MIC50NANANANANANA
        Range≤0.03–0.52>324–82–40.25–1
    M. indicus (10)
        GM0.042.56416.013.02.8
        MIC500.032>32>881
        Range≤0.03–0.1252–4>32>82–80.25–8
    M. irregularis (7)
        GM0.031.86410.84.00.3
        MIC50NANANANANANA
        Range≤0.031–2>324–80.5–80.125–2
    M. janssenii (5)
        GM0.081.5643.01.50.3
        MIC50NANANA420.125
        Range≤0.03–0.51–4>322–40.5–40.06–0.5
    M. lusitanicus (13)
        GM0.082.56413.612.39.4
        MIC500.062>32>888
        Range≤0.03–0.251–4>324–82–81–8
    M. racemosus (4)
        GM0.062.02.80.30.60.1
        MIC50NANANANANANA
        Range≤0.03–0.51–40.06–32≤0.016–20.016–20.016–0.5
    M. ramosissimus (1)
        GM
        MIC50
        Range0.061>32>8>8>8
    M. variicolumellatus (2)
        GM0.031.4645.70.70.7
        MIC50NANANANANANA
        Range≤0.031–2>324–80.5–10.5–1
    M. velutinosus (7)
        GM0.042.2642.41.10.3
        MIC50NANANANANANA
        Range≤0.03–0.1252–4>322–40.5–40.125–2
    Mucoraceae
        GM0.062.0251.096.593.570.98
        MIC500.032>32820.5
        Range≤0.03–0.51–20.06–32≤0.016–80.016–80.016–8
    R. arrhizus (6)
        GM0.24.557.01.11.80.3
        MIC50NANANANANANA
        Range≤0.03–22–832–320.5–40.5–80.125–1
    R. microsporus (6)
        GM0.62.60.11.72.20.5
        MIC50NANANANANANA
        Range0.25–12–4≤0.06–0.51–41–80.125–2
    Rhizopus spp.
        GM0,413.52.641.3720.37
        MIC500.540.5110.5
        Range≤0.03–22–8≤0.06–320.5–40.5–80.125–2
    L. ramosa (2)
        GM0.032.00.182.80.70.06
        MIC50NANANANANANA
        Range≤0.0320.125–0.252–40.25–20.03–0.125
    L. corymbifera (8)
        GM0.112.80.091.80.50.1
        MIC50NANANANANANA
        Range≤0.03–0.52–4≤0.06–0.250.5–40.25–20.06–0.5
    Lichtheimia spp.
        GM0.092.640.1020.570,12
        MIC500.12520.0620.50.125
        Range≤0.03–0.52–4≤0.06–0.250.5–40.25–20.03–0.5
    R. pusillus (4)
        GM0.072.50.12.80.20.1
        MIC50NANANANANANA
        Range≤0.03–0.252–4≤0.06–10.25–80.125–80.03–1
    Lichtheimiaceae
        GM0.072,560.112.10,530,11
        MIC500.0620.0620.50.125
        Range≤0.03–0.52–4≤0.06–10.25–80.125–80.03–1
    • ↵a AMB, amphotericin B; NAT, natamycin; TRB, terbinafine; ISA, isavuconazole; ITC, itraconazole; POS, posaconazole.

    • ↵b GM, geometric mean.

    • ↵c NA, not applicable.

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A Revised Species Concept for Opportunistic Mucor Species Reveals Species-Specific Antifungal Susceptibility Profiles
Lysett Wagner, Sybren de Hoog, Ana Alastruey-Izquierdo, Kerstin Voigt, Oliver Kurzai, Grit Walther
Antimicrobial Agents and Chemotherapy Jul 2019, 63 (8) e00653-19; DOI: 10.1128/AAC.00653-19

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A Revised Species Concept for Opportunistic Mucor Species Reveals Species-Specific Antifungal Susceptibility Profiles
Lysett Wagner, Sybren de Hoog, Ana Alastruey-Izquierdo, Kerstin Voigt, Oliver Kurzai, Grit Walther
Antimicrobial Agents and Chemotherapy Jul 2019, 63 (8) e00653-19; DOI: 10.1128/AAC.00653-19
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    • ABSTRACT
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KEYWORDS

Cokeromyces
Mucor
Mucorales
amphotericin B
antifungal susceptibility testing
isavuconazole
itraconazole
posaconazole
terbinafine
voriconazole

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