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Epidemiology and Surveillance

Evolution and Genetic Diversity of the k13 Gene Associated with Artemisinin Delayed Parasite Clearance in Plasmodium falciparum

M. Andreína Pacheco, Esha R. Kadakia, Zainab Chaudhary, Douglas J. Perkins, Julia Kelley, Shashidhar Ravishankar, Michael Cranfield, Eldin Talundzic, Venkatachalam Udhayakumar, Ananias A. Escalante
M. Andreína Pacheco
aDepartment of Biology/Institute for Genomics and Evolutionary Medicine (iGEM), Temple University, Philadelphia, Pennsylvania, USA
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Esha R. Kadakia
aDepartment of Biology/Institute for Genomics and Evolutionary Medicine (iGEM), Temple University, Philadelphia, Pennsylvania, USA
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Zainab Chaudhary
aDepartment of Biology/Institute for Genomics and Evolutionary Medicine (iGEM), Temple University, Philadelphia, Pennsylvania, USA
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Douglas J. Perkins
bCenter for Global Health, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA
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Julia Kelley
cAtlanta Research and Education Foundation, VAMC, Atlanta, Georgia, USA
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Shashidhar Ravishankar
dSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia, USA
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Michael Cranfield
eGorilla Doctors, Wildlife Health Department, University of California, Davis, Davis, California, USA
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Eldin Talundzic
fMalaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
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Venkatachalam Udhayakumar
fMalaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
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Ananias A. Escalante
aDepartment of Biology/Institute for Genomics and Evolutionary Medicine (iGEM), Temple University, Philadelphia, Pennsylvania, USA
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DOI: 10.1128/AAC.02550-18
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Article Information

DOI 
https://doi.org/10.1128/AAC.02550-18
PubMed 
31085516

Published By 
American Society for Microbiology Journals
History 
  • Received December 5, 2018
  • Returned for modification February 24, 2019
  • Accepted April 28, 2019
  • Published online July 25, 2019.

Copyright & Usage 
Copyright © 2019 American Society for Microbiology. All Rights Reserved.

Article Versions

  • Accepted Manuscript version (May 13, 2019).
  • You are viewing the most recent version of this article.

Author Information

  1. M. Andreína Pachecoa,
  2. Esha R. Kadakiaa,
  3. Zainab Chaudharya,
  4. Douglas J. Perkinsb,
  5. Julia Kelleyc,
  6. Shashidhar Ravishankard,
  7. Michael Cranfielde,
  8. Eldin Talundzicf,
  9. Venkatachalam Udhayakumarf and
  10. Ananias A. Escalantea
  1. aDepartment of Biology/Institute for Genomics and Evolutionary Medicine (iGEM), Temple University, Philadelphia, Pennsylvania, USA
  2. bCenter for Global Health, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA
  3. cAtlanta Research and Education Foundation, VAMC, Atlanta, Georgia, USA
  4. dSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia, USA
  5. eGorilla Doctors, Wildlife Health Department, University of California, Davis, Davis, California, USA
  6. fMalaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
  • Address correspondence to Ananias A. Escalante, Ananias.Escalante{at}temple.edu.
  • Citation Pacheco MA, Kadakia ER, Chaudhary Z, Perkins DJ, Kelley J, Ravishankar S, Cranfield M, Talundzic E, Udhayakumar V, Escalante AA. 2019. Evolution and genetic diversity of the k13 gene associated with artemisinin delayed parasite clearance in Plasmodium falciparum. Antimicrob Agents Chemother 63:e02550-18. https://doi.org/10.1128/AAC.02550-18.

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Evolution and Genetic Diversity of the k13 Gene Associated with Artemisinin Delayed Parasite Clearance in Plasmodium falciparum
M. Andreína Pacheco, Esha R. Kadakia, Zainab Chaudhary, Douglas J. Perkins, Julia Kelley, Shashidhar Ravishankar, Michael Cranfield, Eldin Talundzic, Venkatachalam Udhayakumar, Ananias A. Escalante
Antimicrobial Agents and Chemotherapy Jul 2019, 63 (8) e02550-18; DOI: 10.1128/AAC.02550-18

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Evolution and Genetic Diversity of the k13 Gene Associated with Artemisinin Delayed Parasite Clearance in Plasmodium falciparum
M. Andreína Pacheco, Esha R. Kadakia, Zainab Chaudhary, Douglas J. Perkins, Julia Kelley, Shashidhar Ravishankar, Michael Cranfield, Eldin Talundzic, Venkatachalam Udhayakumar, Ananias A. Escalante
Antimicrobial Agents and Chemotherapy Jul 2019, 63 (8) e02550-18; DOI: 10.1128/AAC.02550-18
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KEYWORDS

Plasmodium falciparum
Plasmodium vivax
artemisinin resistance
k13 gene
kelch propeller domain
rates of evolution

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