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Experimental Therapeutics

In Vivo Pharmacodynamic Study of Cefiderocol, a Novel Parenteral Siderophore Cephalosporin, in Murine Thigh and Lung Infection Models

Rio Nakamura, Tsukasa Ito-Horiyama, Miki Takemura, Shinsuke Toba, Shuhei Matsumoto, Tatsuya Ikehara, Masakatsu Tsuji, Takafumi Sato, Yoshinori Yamano
Rio Nakamura
aDrug Discovery & Disease Research Laboratory, Shionogi & Co., Ltd., Osaka, Japan
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Tsukasa Ito-Horiyama
aDrug Discovery & Disease Research Laboratory, Shionogi & Co., Ltd., Osaka, Japan
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Miki Takemura
aDrug Discovery & Disease Research Laboratory, Shionogi & Co., Ltd., Osaka, Japan
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Shinsuke Toba
aDrug Discovery & Disease Research Laboratory, Shionogi & Co., Ltd., Osaka, Japan
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Shuhei Matsumoto
aDrug Discovery & Disease Research Laboratory, Shionogi & Co., Ltd., Osaka, Japan
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  • ORCID record for Shuhei Matsumoto
Tatsuya Ikehara
aDrug Discovery & Disease Research Laboratory, Shionogi & Co., Ltd., Osaka, Japan
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Masakatsu Tsuji
aDrug Discovery & Disease Research Laboratory, Shionogi & Co., Ltd., Osaka, Japan
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Takafumi Sato
aDrug Discovery & Disease Research Laboratory, Shionogi & Co., Ltd., Osaka, Japan
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Yoshinori Yamano
aDrug Discovery & Disease Research Laboratory, Shionogi & Co., Ltd., Osaka, Japan
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DOI: 10.1128/AAC.02031-18
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Article Information

DOI 
https://doi.org/10.1128/AAC.02031-18
PubMed 
31262762

Published By 
American Society for Microbiology Journals
History 
  • Received October 4, 2018
  • Returned for modification December 15, 2018
  • Accepted June 2, 2019
  • Published online August 23, 2019.

Copyright & Usage 
Copyright © 2019 Nakamura et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

Article Versions

  • Accepted Manuscript version (July 01, 2019).
  • Accepted Manuscript version (July 29, 2019).
  • You are viewing the most recent version of this article.

Author Information

  1. Rio Nakamuraa,
  2. Tsukasa Ito-Horiyamaa,
  3. Miki Takemuraa,
  4. Shinsuke Tobaa,
  5. Shuhei Matsumotoa,
  6. Tatsuya Ikeharaa,
  7. Masakatsu Tsujia,
  8. Takafumi Satoa and
  9. Yoshinori Yamanoa
  1. aDrug Discovery & Disease Research Laboratory, Shionogi & Co., Ltd., Osaka, Japan
  • Address correspondence to Rio Nakamura, rio.nakamura{at}shionogi.co.jp.
  • Citation Nakamura R, Ito-Horiyama T, Takemura M, Toba S, Matsumoto S, Ikehara T, Tsuji M, Sato T, Yamano Y. 2019. In vivo pharmacodynamic study of cefiderocol, a novel parenteral siderophore cephalosporin, in murine thigh and lung infection models. Antimicrob Agents Chemother 63:e02031-18. https://doi.org/10.1128/AAC.02031-18.

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In Vivo Pharmacodynamic Study of Cefiderocol, a Novel Parenteral Siderophore Cephalosporin, in Murine Thigh and Lung Infection Models
Rio Nakamura, Tsukasa Ito-Horiyama, Miki Takemura, Shinsuke Toba, Shuhei Matsumoto, Tatsuya Ikehara, Masakatsu Tsuji, Takafumi Sato, Yoshinori Yamano
Antimicrobial Agents and Chemotherapy Aug 2019, 63 (9) e02031-18; DOI: 10.1128/AAC.02031-18

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In Vivo Pharmacodynamic Study of Cefiderocol, a Novel Parenteral Siderophore Cephalosporin, in Murine Thigh and Lung Infection Models
Rio Nakamura, Tsukasa Ito-Horiyama, Miki Takemura, Shinsuke Toba, Shuhei Matsumoto, Tatsuya Ikehara, Masakatsu Tsuji, Takafumi Sato, Yoshinori Yamano
Antimicrobial Agents and Chemotherapy Aug 2019, 63 (9) e02031-18; DOI: 10.1128/AAC.02031-18
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KEYWORDS

Acinetobacter baumannii
CRE
Pseudomonas aeruginosa
PK/PD
Stenotrophomonas maltophilia
cefiderocol
in vivo
lung infection
multidrug resistance
thigh infection

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