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Mechanisms of Action: Physiological Effects

DAV131A Protects Hamsters from Lethal Clostridioides difficile Infection Induced by Fluoroquinolones

Nathalie Saint-Lu, Charles Burdet, Frédérique Sablier-Gallis, Tanguy Corbel, Agathe Nevière, Sakina Sayah-Jeanne, Mark Pulse, William Weiss, Stéphanie Ferreira, Antoine Andremont, France Mentré, Jean de Gunzburg
Nathalie Saint-Lu
aDa Volterra, Paris, France
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Charles Burdet
bUniversité de Paris, IAME, INSERM, Paris, France
cAP-HP, Bichat Hospital, Department of Epidemiology, Biostatistics, and Clinical Research, Paris, France
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Frédérique Sablier-Gallis
aDa Volterra, Paris, France
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Tanguy Corbel
aDa Volterra, Paris, France
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Agathe Nevière
aDa Volterra, Paris, France
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Sakina Sayah-Jeanne
aDa Volterra, Paris, France
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Mark Pulse
dUNT Health Science Center, Fort Worth, Texas, USA
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William Weiss
dUNT Health Science Center, Fort Worth, Texas, USA
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Stéphanie Ferreira
eGenoScreen, Lille, France
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Antoine Andremont
bUniversité de Paris, IAME, INSERM, Paris, France
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France Mentré
bUniversité de Paris, IAME, INSERM, Paris, France
cAP-HP, Bichat Hospital, Department of Epidemiology, Biostatistics, and Clinical Research, Paris, France
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Jean de Gunzburg
aDa Volterra, Paris, France
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  • ORCID record for Jean de Gunzburg
DOI: 10.1128/AAC.01196-19
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Article Information

DOI 
https://doi.org/10.1128/AAC.01196-19
PubMed 
31636067

Published By 
American Society for Microbiology Journals
History 
  • Received June 12, 2019
  • Returned for modification July 28, 2019
  • Accepted October 8, 2019
  • Published online December 20, 2019.

Copyright & Usage 
Copyright © 2019 American Society for Microbiology. All Rights Reserved.

Article Versions

  • Accepted Manuscript version (October 21, 2019).
  • You are viewing the most recent version of this article.

Author Information

  1. Nathalie Saint-Lua,
  2. Charles Burdetb,c,
  3. Frédérique Sablier-Gallisa,
  4. Tanguy Corbela,
  5. Agathe Nevièrea,
  6. Sakina Sayah-Jeannea,
  7. Mark Pulsed,
  8. William Weissd,
  9. Stéphanie Ferreirae,
  10. Antoine Andremontb,
  11. France Mentréb,c and
  12. Jean de Gunzburga
  1. aDa Volterra, Paris, France
  2. bUniversité de Paris, IAME, INSERM, Paris, France
  3. cAP-HP, Bichat Hospital, Department of Epidemiology, Biostatistics, and Clinical Research, Paris, France
  4. dUNT Health Science Center, Fort Worth, Texas, USA
  5. eGenoScreen, Lille, France
  • Address correspondence to Jean de Gunzburg, gunzburg{at}davolterra.com.
  • Citation Saint-Lu N, Burdet C, Sablier-Gallis F, Corbel T, Nevière A, Sayah-Jeanne S, Pulse M, Weiss W, Ferreira S, Andremont A, Mentré F, de Gunzburg J. 2020. DAV131A protects hamsters from lethal Clostridioides difficile infection induced by fluoroquinolones. Antimicrob Agents Chemother 64:e01196-19. https://doi.org/10.1128/AAC.01196-19.

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DAV131A Protects Hamsters from Lethal Clostridioides difficile Infection Induced by Fluoroquinolones
Nathalie Saint-Lu, Charles Burdet, Frédérique Sablier-Gallis, Tanguy Corbel, Agathe Nevière, Sakina Sayah-Jeanne, Mark Pulse, William Weiss, Stéphanie Ferreira, Antoine Andremont, France Mentré, Jean de Gunzburg
Antimicrobial Agents and Chemotherapy Dec 2019, 64 (1) e01196-19; DOI: 10.1128/AAC.01196-19

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DAV131A Protects Hamsters from Lethal Clostridioides difficile Infection Induced by Fluoroquinolones
Nathalie Saint-Lu, Charles Burdet, Frédérique Sablier-Gallis, Tanguy Corbel, Agathe Nevière, Sakina Sayah-Jeanne, Mark Pulse, William Weiss, Stéphanie Ferreira, Antoine Andremont, France Mentré, Jean de Gunzburg
Antimicrobial Agents and Chemotherapy Dec 2019, 64 (1) e01196-19; DOI: 10.1128/AAC.01196-19
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KEYWORDS

Clostridioides difficile infection
antibiotics
dysbiosis
fluoroquinolones
hamster animal model
prevention

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