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Mechanisms of Resistance

Modification of pfap2μ and pfubp1 Markedly Reduces Ring-Stage Susceptibility of Plasmodium falciparum to Artemisinin In Vitro

Ryan C. Henrici, Donelly A. van Schalkwyk, Colin J. Sutherland
Ryan C. Henrici
aDepartment of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
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Donelly A. van Schalkwyk
aDepartment of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
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Colin J. Sutherland
aDepartment of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
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DOI: 10.1128/AAC.01542-19
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Article Information

DOI 
https://doi.org/10.1128/AAC.01542-19
PubMed 
31636063

Published By 
American Society for Microbiology Journals
History 
  • Received July 30, 2019
  • Returned for modification September 1, 2019
  • Accepted October 10, 2019
  • Published online December 20, 2019.

Copyright & Usage 
Copyright © 2019 American Society for Microbiology. All Rights Reserved.

Article Versions

  • Accepted Manuscript version (October 21, 2019).
  • You are viewing the most recent version of this article.

Author Information

  1. Ryan C. Henricia,
  2. Donelly A. van Schalkwyka and
  3. Colin J. Sutherlanda
  1. aDepartment of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
  • Address correspondence to Colin J. Sutherland, colin.sutherland{at}lshtm.ac.uk.
  • Citation Henrici RC, van Schalkwyk DA, Sutherland CJ. 2020. Modification of pfap2μ and pfubp1 markedly reduces ring-stage susceptibility of Plasmodium falciparum to artemisinin in vitro. Antimicrob Agents Chemother 64:e01542-19. https://doi.org/10.1128/AAC.01542-19.

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Modification of pfap2μ and pfubp1 Markedly Reduces Ring-Stage Susceptibility of Plasmodium falciparum to Artemisinin In Vitro
Ryan C. Henrici, Donelly A. van Schalkwyk, Colin J. Sutherland
Antimicrobial Agents and Chemotherapy Dec 2019, 64 (1) e01542-19; DOI: 10.1128/AAC.01542-19

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Modification of pfap2μ and pfubp1 Markedly Reduces Ring-Stage Susceptibility of Plasmodium falciparum to Artemisinin In Vitro
Ryan C. Henrici, Donelly A. van Schalkwyk, Colin J. Sutherland
Antimicrobial Agents and Chemotherapy Dec 2019, 64 (1) e01542-19; DOI: 10.1128/AAC.01542-19
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KEYWORDS

Plasmodium falciparum
antimalarial agents
gene editing
susceptibility

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