DOI: 10.1128/AAC.01639-19
ABSTRACT
For HIV cure strategies like “kick and kill” to succeed, antiretroviral (ARV) drugs must reach effective concentrations in putative viral reservoirs. We characterize penetration of six ARVs in three preclinical animal models and humans. We found that standard dosing strategies in preclinical species closely mimicked tissue concentrations in humans for some, but not all, ARVs. These results have implications for interpreting HIV treatment, prevention, or cure interventions between preclinical and clinical models.
FOOTNOTES
- Received 26 August 2019.
- Returned for modification 19 September 2019.
- Accepted 8 October 2019.
- Accepted manuscript posted online 14 October 2019.
Supplemental material is available online only.
- Copyright © 2019 American Society for Microbiology.
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