Natural Polymorphisms in Mycobacterium tuberculosis Conferring Resistance to Delamanid in Drug-Naive Patients

DOI: 10.1128/AAC.00513-20

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Martina L. Reichmuth^a,
Rico Hömke^b,^c,
Kathrin Zürcher^a,
Peter Sander^b,^c,
Anchalee Avihingsanon^d,
Jimena Collantes^e,
Chloé Loiseau^f,^g,
Sonia Borrell^f,^g,
Miriam Reinhard^f,^g,
Robert J. Wilkinson^h,ⁱ,^j,
Marcel Yotebieng^k,^l,
Lukas Fenner^a,
Erik C. Böttger^b,^c,
Sebastien Gagneux^f,^g,
Matthias Egger^a,^m and
Peter M. Keller^b,^c,ⁿ
on behalf of the International epidemiology Databases to Evaluate AIDS (IeDEA)

^aInstitute of Social and Preventive Medicine, University of Bern, Bern, Switzerland
^bInstitute of Medical Microbiology, University of Zurich, Zurich, Switzerland
^cSwiss National Center for Mycobacteria, Zurich, Switzerland
^dThe HIV Netherlands Australia Thailand (HIV-NAT) Research Collaboration, Thai Red Cross AIDS Research Centre and Tuberculosis Research Unit, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
^eInstituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru
^fSwiss Tropical and Public Health Institute, Basel, Switzerland
^gUniversity of Basel, Basel, Switzerland
^hWellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, Cape Town, Republic of South Africa
ⁱDepartment of Infectious Diseases, Imperial College, London, United Kingdom
^jThe Francis Crick Institute, London, United Kingdom
^kNational TB Lab, Kinshasa, Democratic Republic of the Congo
^lAlbert Einstein College of Medicine, New York, New York, USA
^mCentre for Infectious Disease Epidemiology and Research, Faculty of Health Sciences, University of Cape Town, Cape Town, Republic of South Africa
ⁿInstitute for Infectious Diseases, University of Bern, Bern, Switzerland

Address correspondence to Peter M. Keller, peter.keller{at}ifik.unibe.ch.
Martina L. Reichmuth and Rico Hömke contributed equally to this work. Author order was determined by decreasing seniority.
Citation Reichmuth ML, Hömke R, Zürcher K, Sander P, Avihingsanon A, Collantes J, Loiseau C, Borrell S, Reinhard M, Wilkinson RJ, Yotebieng M, Fenner L, Böttger EC, Gagneux S, Egger M, Keller PM, on behalf of the International epidemiology Databases to Evaluate AIDS (IeDEA). 2020. Natural polymorphisms in Mycobacterium tuberculosis conferring resistance to delamanid in drug-naive patients. Antimicrob Agents Chemother 64:e00513-20. https://doi.org/10.1128/AAC.00513-20.