Natural Polymorphisms in Mycobacterium tuberculosis Conferring Resistance to Delamanid in Drug-Naive Patients

Martina L. Reichmuth; Rico Hömke; Kathrin Zürcher; Peter Sander; Anchalee Avihingsanon; Jimena Collantes; Chloé Loiseau; Sonia Borrell; Miriam Reinhard; Robert J. Wilkinson; Marcel Yotebieng; Lukas Fenner; Erik C. Böttger; Sebastien Gagneux; Matthias Egger; Peter M. Keller

doi:10.1128/AAC.00513-20

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Natural Polymorphisms in Mycobacterium tuberculosis Conferring Resistance to Delamanid in Drug-Naive Patients

Martina L. Reichmuth, Rico Hömke, Kathrin Zürcher, Peter Sander, Anchalee Avihingsanon, Jimena Collantes, Chloé Loiseau, Sonia Borrell, Miriam Reinhard, Robert J. Wilkinson, Marcel Yotebieng, Lukas Fenner, Erik C. Böttger, Sebastien Gagneux, Matthias Egger, Peter M. Keller

Martina L. Reichmuth

aInstitute of Social and Preventive Medicine, University of Bern, Bern, Switzerland

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Rico Hömke

bInstitute of Medical Microbiology, University of Zurich, Zurich, Switzerland

cSwiss National Center for Mycobacteria, Zurich, Switzerland

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Kathrin Zürcher

aInstitute of Social and Preventive Medicine, University of Bern, Bern, Switzerland

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Peter Sander

bInstitute of Medical Microbiology, University of Zurich, Zurich, Switzerland

cSwiss National Center for Mycobacteria, Zurich, Switzerland

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Anchalee Avihingsanon

dThe HIV Netherlands Australia Thailand (HIV-NAT) Research Collaboration, Thai Red Cross AIDS Research Centre and Tuberculosis Research Unit, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand

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Jimena Collantes

eInstituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru

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Chloé Loiseau

fSwiss Tropical and Public Health Institute, Basel, Switzerland

gUniversity of Basel, Basel, Switzerland

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Sonia Borrell

fSwiss Tropical and Public Health Institute, Basel, Switzerland

gUniversity of Basel, Basel, Switzerland

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Miriam Reinhard

fSwiss Tropical and Public Health Institute, Basel, Switzerland

gUniversity of Basel, Basel, Switzerland

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Robert J. Wilkinson

hWellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, Cape Town, Republic of South Africa

iDepartment of Infectious Diseases, Imperial College, London, United Kingdom

jThe Francis Crick Institute, London, United Kingdom

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Marcel Yotebieng

kNational TB Lab, Kinshasa, Democratic Republic of the Congo

lAlbert Einstein College of Medicine, New York, New York, USA

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Lukas Fenner

aInstitute of Social and Preventive Medicine, University of Bern, Bern, Switzerland

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Erik C. Böttger

bInstitute of Medical Microbiology, University of Zurich, Zurich, Switzerland

cSwiss National Center for Mycobacteria, Zurich, Switzerland

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Sebastien Gagneux

fSwiss Tropical and Public Health Institute, Basel, Switzerland

gUniversity of Basel, Basel, Switzerland

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Matthias Egger

aInstitute of Social and Preventive Medicine, University of Bern, Bern, Switzerland

mCentre for Infectious Disease Epidemiology and Research, Faculty of Health Sciences, University of Cape Town, Cape Town, Republic of South Africa

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Peter M. Keller

bInstitute of Medical Microbiology, University of Zurich, Zurich, Switzerland

cSwiss National Center for Mycobacteria, Zurich, Switzerland

nInstitute for Infectious Diseases, University of Bern, Bern, Switzerland

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DOI: 10.1128/AAC.00513-20

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TABLE 1
Observed polymorphisms in F₄₂₀ genes and MIC values of delamanid^a
↵a All patients were treated with 2 months of daily isoniazid, rifampin, pyrazinamide, and ethambutol, followed by 4 months of daily rifampin and isoniazid. Data for isolates for which the MIC was >0.015 are shown in boldface. wt, wild type; L, lineage.

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Natural Polymorphisms in Mycobacterium tuberculosis Conferring Resistance to Delamanid in Drug-Naive Patients

Antimicrobial Agents and Chemotherapy Oct 2020, 64 (11) e00513-20; DOI: 10.1128/AAC.00513-20

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