DOI: 10.1128/AAC.01885-19
ABSTRACT
In vitro synergy between an antimicrobial protein lysin (cell wall hydrolase) called exebacase and each of 12 different antibiotics was examined against Staphylococcus aureus isolates using a nonstandard medium approved for exebacase susceptibility testing by the Clinical and Laboratory Standards Institute. In the checkerboard assay format, fractional inhibitory concentration index values of ≤0.5, consistent with synergy, were observed for the majority of interactions tested. Synergy was further confirmed in time-kill assays.
FOOTNOTES
- Received 16 September 2019.
- Returned for modification 11 October 2019.
- Accepted 6 November 2019.
- Accepted manuscript posted online 11 November 2019.
Supplemental material is available online only.
- Copyright © 2020 American Society for Microbiology.
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