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Pharmacology

Ex Vivo Urinary Bactericidal Activity and Urinary Pharmacodynamics of Fosfomycin after Two Repeated Dosing Regimens of Oral Fosfomycin Tromethamine in Healthy Adult Subjects

E. Wenzler, K. M. Meyer, S. C. Bleasdale, M. Sikka, R. E. Mendes, K. L. Bunnell, M. Finnemeyer, S. L. Rosenkranz, L. H. Danziger, K. A. Rodvold
E. Wenzler
aCollege of Pharmacy, University of Illinois at Chicago, Chicago, Illinois, USA
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K. M. Meyer
aCollege of Pharmacy, University of Illinois at Chicago, Chicago, Illinois, USA
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S. C. Bleasdale
bCollege of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA
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M. Sikka
bCollege of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA
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R. E. Mendes
cJMI Laboratories, North Liberty, Iowa, USA
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K. L. Bunnell
aCollege of Pharmacy, University of Illinois at Chicago, Chicago, Illinois, USA
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M. Finnemeyer
dHarvard TH Chan School of Public Health, Boston, Massachusetts, USA
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S. L. Rosenkranz
dHarvard TH Chan School of Public Health, Boston, Massachusetts, USA
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L. H. Danziger
aCollege of Pharmacy, University of Illinois at Chicago, Chicago, Illinois, USA
bCollege of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA
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K. A. Rodvold
aCollege of Pharmacy, University of Illinois at Chicago, Chicago, Illinois, USA
bCollege of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA
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DOI: 10.1128/AAC.02102-19
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Article Information

DOI 
https://doi.org/10.1128/AAC.02102-19
PubMed 
31767717

Published By 
American Society for Microbiology Journals
History 
  • Received October 17, 2019
  • Returned for modification November 10, 2019
  • Accepted November 14, 2019
  • Published online January 27, 2020.

Copyright & Usage 
Copyright © 2020 American Society for Microbiology. All Rights Reserved.

Article Versions

  • Accepted Manuscript version (November 25, 2019).
  • You are viewing the most recent version of this article.

Author Information

  1. E. Wenzlera,
  2. K. M. Meyera,
  3. S. C. Bleasdaleb,
  4. M. Sikkab*,
  5. R. E. Mendesc,
  6. K. L. Bunnella*,
  7. M. Finnemeyerd,
  8. S. L. Rosenkranzd,
  9. L. H. Danzigera,b and
  10. K. A. Rodvolda,b
  11. for the Antibacterial Resistance Leadership Group
  1. aCollege of Pharmacy, University of Illinois at Chicago, Chicago, Illinois, USA
  2. bCollege of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA
  3. cJMI Laboratories, North Liberty, Iowa, USA
  4. dHarvard TH Chan School of Public Health, Boston, Massachusetts, USA
  • Address correspondence to K. A. Rodvold, kar{at}uic.edu.
  • ↵* Present address: M. Sikka, Oregon Health & Science University, Portland, Oregon, USA; K. L. Bunnell, Medical College of Wisconsin School of Pharmacy, Milwaukee, Wisconsin, USA.

  • Citation Wenzler E, Meyer KM, Bleasdale SC, Sikka M, Mendes RE, Bunnell KL, Finnemeyer M, Rosenkranz SL, Danziger LH, Rodvold KA, for the Antibacterial Resistance Leadership Group. 2020. Ex vivo urinary bactericidal activity and urinary pharmacodynamics of fosfomycin after two repeated dosing regimens of oral fosfomycin tromethamine in healthy adult subjects. Antimicrob Agents Chemother 64:e02102-19. https://doi.org/10.1128/AAC.02102-19.

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Ex Vivo Urinary Bactericidal Activity and Urinary Pharmacodynamics of Fosfomycin after Two Repeated Dosing Regimens of Oral Fosfomycin Tromethamine in Healthy Adult Subjects
E. Wenzler, K. M. Meyer, S. C. Bleasdale, M. Sikka, R. E. Mendes, K. L. Bunnell, M. Finnemeyer, S. L. Rosenkranz, L. H. Danziger, K. A. Rodvold for the Antibacterial Resistance Leadership Group
Antimicrobial Agents and Chemotherapy Jan 2020, 64 (2) e02102-19; DOI: 10.1128/AAC.02102-19

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Ex Vivo Urinary Bactericidal Activity and Urinary Pharmacodynamics of Fosfomycin after Two Repeated Dosing Regimens of Oral Fosfomycin Tromethamine in Healthy Adult Subjects
E. Wenzler, K. M. Meyer, S. C. Bleasdale, M. Sikka, R. E. Mendes, K. L. Bunnell, M. Finnemeyer, S. L. Rosenkranz, L. H. Danziger, K. A. Rodvold for the Antibacterial Resistance Leadership Group
Antimicrobial Agents and Chemotherapy Jan 2020, 64 (2) e02102-19; DOI: 10.1128/AAC.02102-19
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KEYWORDS

fosfomycin
urinary bactericidal titers
pharmacodynamics
urine
urinary tract infection

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