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Fact versus Fiction: a Review of the Evidence behind Alcohol and Antibiotic Interactions

Kari A. Mergenhagen, Bethany A. Wattengel, Megan K. Skelly, Collin M. Clark, Thomas A. Russo
DOI: 10.1128/AAC.02167-19

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Figures

Tables

  • TABLE 1

    Comparison of alcohol warnings from various retail pharmaciesa

    TABLE 1

    • ↵a Antibiotics for which there are no warnings from Walgreen’s, Rite Aid, or CVS: cephalexin, cefdinir, doxycycline, nitrofurantoin, azithromycin, erythromycin, penicillin, and amoxicillin.

  • TABLE 2

    Overall recommendations for use with alcohol

    TABLE 2

    • ↵a Caution should be exercised, as robust data are lacking.

    • ↵b i.v., intravenous; i.m., intramuscular.

  • TABLE 3

    Summary of alcohol and antimicrobial interactions with a moderate strength of evidence

    TABLE 3

    • ↵a Carries a risk of hepatoxicity.

  • TABLE 4

    Summary of alcohol and antimicrobial interactions with a poor strength of evidence

    TABLE 4

    • ↵a Carries a risk of hepatoxicity.

    • ↵b Caution should be exercised as robust data are lacking.

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KEYWORDS

adverse drug effects
antimicrobial agents
antimicrobial safety
drug interactions

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