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Mechanisms of Action: Physiological Effects

Synergistic Interactions of Indole-2-Carboxamides and β-Lactam Antibiotics against Mycobacterium abscessus

Clément Raynaud, Wassim Daher, Françoise Roquet-Banères, Matt D. Johansen, Jozef Stec, Oluseye K. Onajole, Diane Ordway, Alan P. Kozikowski, Laurent Kremer
Clément Raynaud
aCentre National de la Recherche Scientifique UMR 9004, Institut de Recherche en Infectiologie de Montpellier (IRIM), Université de Montpellier, Montpellier, France
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Wassim Daher
aCentre National de la Recherche Scientifique UMR 9004, Institut de Recherche en Infectiologie de Montpellier (IRIM), Université de Montpellier, Montpellier, France
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Françoise Roquet-Banères
aCentre National de la Recherche Scientifique UMR 9004, Institut de Recherche en Infectiologie de Montpellier (IRIM), Université de Montpellier, Montpellier, France
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Matt D. Johansen
aCentre National de la Recherche Scientifique UMR 9004, Institut de Recherche en Infectiologie de Montpellier (IRIM), Université de Montpellier, Montpellier, France
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  • ORCID record for Matt D. Johansen
Jozef Stec
cDepartment of Pharmaceutical Sciences, College of Pharmacy, Marshall B. Ketchum University, Fullerton, California, USA
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Oluseye K. Onajole
dDepartment of Biological, Physical and Health Sciences, Roosevelt University, Chicago, Illinois, USA
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Diane Ordway
eColorado State University, Department of Microbiology, Immunology & Pathology, Mycobacteria Research Laboratory, Fort Collins, Colorado, USA
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Alan P. Kozikowski
fStarWise Therapeutics LLC, Chicago, Illinois, USA
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Laurent Kremer
aCentre National de la Recherche Scientifique UMR 9004, Institut de Recherche en Infectiologie de Montpellier (IRIM), Université de Montpellier, Montpellier, France
bINSERM, IRIM, Montpellier, France
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DOI: 10.1128/AAC.02548-19
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Article Information

DOI 
https://doi.org/10.1128/AAC.02548-19
PubMed 
32041716

Published By 
American Society for Microbiology Journals
History 
  • Received December 20, 2019
  • Returned for modification January 24, 2020
  • Accepted February 6, 2020
  • Published online April 21, 2020.

Copyright & Usage 
Copyright © 2020 American Society for Microbiology. All Rights Reserved.

Article Versions

  • Accepted Manuscript version (February 10, 2020).
  • You are viewing the most recent version of this article.

Author Information

  1. Clément Raynauda,
  2. Wassim Dahera,
  3. Françoise Roquet-Banèresa,
  4. Matt D. Johansena,
  5. Jozef Stecc,
  6. Oluseye K. Onajoled,
  7. Diane Ordwaye,
  8. Alan P. Kozikowskif and
  9. Laurent Kremera,b
  1. aCentre National de la Recherche Scientifique UMR 9004, Institut de Recherche en Infectiologie de Montpellier (IRIM), Université de Montpellier, Montpellier, France
  2. bINSERM, IRIM, Montpellier, France
  3. cDepartment of Pharmaceutical Sciences, College of Pharmacy, Marshall B. Ketchum University, Fullerton, California, USA
  4. dDepartment of Biological, Physical and Health Sciences, Roosevelt University, Chicago, Illinois, USA
  5. eColorado State University, Department of Microbiology, Immunology & Pathology, Mycobacteria Research Laboratory, Fort Collins, Colorado, USA
  6. fStarWise Therapeutics LLC, Chicago, Illinois, USA
  • Address correspondence to Laurent Kremer, laurent.kremer{at}irim.cnrs.fr.
  • Citation Raynaud C, Daher W, Roquet-Banères F, Johansen MD, Stec J, Onajole OK, Ordway D, Kozikowski AP, Kremer L. 2020. Synergistic interactions of indole-2-carboxamides and β-lactam antibiotics against Mycobacterium abscessus. Antimicrob Agents Chemother 64:e02548-19. https://doi.org/10.1128/AAC.02548-19.

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Synergistic Interactions of Indole-2-Carboxamides and β-Lactam Antibiotics against Mycobacterium abscessus
Clément Raynaud, Wassim Daher, Françoise Roquet-Banères, Matt D. Johansen, Jozef Stec, Oluseye K. Onajole, Diane Ordway, Alan P. Kozikowski, Laurent Kremer
Antimicrobial Agents and Chemotherapy Apr 2020, 64 (5) e02548-19; DOI: 10.1128/AAC.02548-19

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Synergistic Interactions of Indole-2-Carboxamides and β-Lactam Antibiotics against Mycobacterium abscessus
Clément Raynaud, Wassim Daher, Françoise Roquet-Banères, Matt D. Johansen, Jozef Stec, Oluseye K. Onajole, Diane Ordway, Alan P. Kozikowski, Laurent Kremer
Antimicrobial Agents and Chemotherapy Apr 2020, 64 (5) e02548-19; DOI: 10.1128/AAC.02548-19
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KEYWORDS

Mycobacterium abscessus
indole-2-carboxamide
β-lactam
MmpL3
drug synergism
macrophage
therapeutic activity

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