DOI: 10.1128/AAC.00114-20
ABSTRACT
Mycobacterium abscessus lung infections remain difficult to treat. Recent studies have recognized the power of new combinations of antibiotics, such as bedaquiline and imipenem, although in vitro data have questioned this combination. We report that the efficacy of bedaquiline-imipenem combination treatment relies essentially on the activity of bedaquiline in a C3HeB/FeJ mice model of infection with a rough variant of M. abscessus. The addition of imipenem contributed to clearing the infection in the spleen.
FOOTNOTES
- Received 17 January 2020.
- Returned for modification 2 March 2020.
- Accepted 26 March 2020.
- Accepted manuscript posted online 6 April 2020.
Supplemental material is available online only.
- Copyright © 2020 American Society for Microbiology.
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