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Experimental Therapeutics

Fosmanogepix (APX001) Is Effective in the Treatment of Pulmonary Murine Mucormycosis Due to Rhizopus arrhizus

Teclegiorgis Gebremariam, Sondus Alkhazraji, Abdullah Alqarihi, Nathan P. Wiederhold, Karen Joy Shaw, Thomas F. Patterson, Scott G. Filler, Ashraf S. Ibrahim
Teclegiorgis Gebremariam
aThe Lundquist Institute for Biomedical Innovations at Harbor-University of California Los Angeles (UCLA) Medical Center, Torrance, California, USA
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Sondus Alkhazraji
aThe Lundquist Institute for Biomedical Innovations at Harbor-University of California Los Angeles (UCLA) Medical Center, Torrance, California, USA
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Abdullah Alqarihi
aThe Lundquist Institute for Biomedical Innovations at Harbor-University of California Los Angeles (UCLA) Medical Center, Torrance, California, USA
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Nathan P. Wiederhold
bUniversity of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
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  • ORCID record for Nathan P. Wiederhold
Karen Joy Shaw
cHearts Consulting Group, San Diego, California, USA
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Thomas F. Patterson
bUniversity of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
dSouth Texas Veterans Health Care System, San Antonio, Texas, USA
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Scott G. Filler
aThe Lundquist Institute for Biomedical Innovations at Harbor-University of California Los Angeles (UCLA) Medical Center, Torrance, California, USA
eDavid Geffen School of Medicine at UCLA, Los Angeles, California, USA
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Ashraf S. Ibrahim
aThe Lundquist Institute for Biomedical Innovations at Harbor-University of California Los Angeles (UCLA) Medical Center, Torrance, California, USA
eDavid Geffen School of Medicine at UCLA, Los Angeles, California, USA
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DOI: 10.1128/AAC.00178-20
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Article Information

DOI 
https://doi.org/10.1128/AAC.00178-20
PubMed 
32205345

Published By 
American Society for Microbiology Journals
History 
  • Received January 23, 2020
  • Returned for modification March 7, 2020
  • Accepted March 17, 2020
  • Published online May 21, 2020.

Copyright & Usage 
Copyright © 2020 Gebremariam et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

Article Versions

  • Accepted Manuscript version (March 23, 2020).
  • You are viewing the most recent version of this article.

Author Information

  1. Teclegiorgis Gebremariama,
  2. Sondus Alkhazrajia,
  3. Abdullah Alqarihia,
  4. Nathan P. Wiederholdb,
  5. Karen Joy Shawc,
  6. Thomas F. Pattersonb,d,
  7. Scott G. Fillera,e and
  8. Ashraf S. Ibrahima,e
  1. aThe Lundquist Institute for Biomedical Innovations at Harbor-University of California Los Angeles (UCLA) Medical Center, Torrance, California, USA
  2. bUniversity of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
  3. cHearts Consulting Group, San Diego, California, USA
  4. dSouth Texas Veterans Health Care System, San Antonio, Texas, USA
  5. eDavid Geffen School of Medicine at UCLA, Los Angeles, California, USA
  • Address correspondence to Karen Joy Shaw, kshaw{at}amplyx.com, or Ashraf S. Ibrahim, ibrahim{at}lundquist.org.
  • Citation Gebremariam T, Alkhazraji S, Alqarihi A, Wiederhold NP, Shaw KJ, Patterson TF, Filler SG, Ibrahim AS. 2020. Fosmanogepix (APX001) is effective in the treatment of pulmonary murine mucormycosis due to Rhizopus arrhizus. Antimicrob Agents Chemother 64:e00178-20. https://doi.org/10.1128/AAC.00178-20.

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Fosmanogepix (APX001) Is Effective in the Treatment of Pulmonary Murine Mucormycosis Due to Rhizopus arrhizus
Teclegiorgis Gebremariam, Sondus Alkhazraji, Abdullah Alqarihi, Nathan P. Wiederhold, Karen Joy Shaw, Thomas F. Patterson, Scott G. Filler, Ashraf S. Ibrahim
Antimicrobial Agents and Chemotherapy May 2020, 64 (6) e00178-20; DOI: 10.1128/AAC.00178-20

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Fosmanogepix (APX001) Is Effective in the Treatment of Pulmonary Murine Mucormycosis Due to Rhizopus arrhizus
Teclegiorgis Gebremariam, Sondus Alkhazraji, Abdullah Alqarihi, Nathan P. Wiederhold, Karen Joy Shaw, Thomas F. Patterson, Scott G. Filler, Ashraf S. Ibrahim
Antimicrobial Agents and Chemotherapy May 2020, 64 (6) e00178-20; DOI: 10.1128/AAC.00178-20
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KEYWORDS

APX001
APX001A
Gwt1
antifungal
Rhizopus arrhizus
infection model
mucormycosis
1-aminobenzotriazole
manogepix
MGX
fosmanogepix
antifungal agents
infectious disease

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