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Mechanisms of Action: Physiological Effects

Leishmanicidal Activity of an In Silico-Screened Novel Inhibitor against Ascorbate Peroxidase of Leishmania donovani

Mohammad Kashif, Ankush Paladhi, Ranjeet Singh, Sankar Bhattacharyya, Sumit Kumar Hira, Partha Pratim Manna
Mohammad Kashif
aImmunobiology Laboratory, Department of Zoology, Institute of Science, Banaras Hindu University, Varanasi, India
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Ankush Paladhi
bCellular Immunology Laboratory, Department of Zoology, The University of Burdwan, Purba Bardhhaman, India
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Ranjeet Singh
aImmunobiology Laboratory, Department of Zoology, Institute of Science, Banaras Hindu University, Varanasi, India
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Sankar Bhattacharyya
cImmunobiology Lab, Department of Zoology, Sidho Kanho Birsha University, Purulia, India
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Sumit Kumar Hira
bCellular Immunology Laboratory, Department of Zoology, The University of Burdwan, Purba Bardhhaman, India
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Partha Pratim Manna
aImmunobiology Laboratory, Department of Zoology, Institute of Science, Banaras Hindu University, Varanasi, India
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DOI: 10.1128/AAC.01766-19
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Article Information

DOI 
https://doi.org/10.1128/AAC.01766-19
PubMed 
32366716

Published By 
American Society for Microbiology Journals
History 
  • Received August 28, 2019
  • Returned for modification October 27, 2019
  • Accepted April 27, 2020
  • Published online June 23, 2020.

Copyright & Usage 
Copyright © 2020 American Society for Microbiology. All Rights Reserved.

Article Versions

  • Accepted Manuscript version (May 04, 2020).
  • You are viewing the most recent version of this article.

Author Information

  1. Mohammad Kashifa,
  2. Ankush Paladhib,
  3. Ranjeet Singha,
  4. Sankar Bhattacharyyac,
  5. Sumit Kumar Hirab and
  6. Partha Pratim Mannaa
  1. aImmunobiology Laboratory, Department of Zoology, Institute of Science, Banaras Hindu University, Varanasi, India
  2. bCellular Immunology Laboratory, Department of Zoology, The University of Burdwan, Purba Bardhhaman, India
  3. cImmunobiology Lab, Department of Zoology, Sidho Kanho Birsha University, Purulia, India
  • Address correspondence to Sumit Kumar Hira, sumit.hira2008{at}gmail.com, or Partha Pratim Manna, pp_manna{at}yahoo.com.
  • Mohammad Kashif and Ankush Paladhi contributed equally to this work. Author order was determined both on the basis of contribution and in order of increasing seniority.

  • Citation Kashif M, Paladhi A, Singh R, Bhattacharyya S, Hira SK, Manna PP. 2020. Leishmanicidal activity of an in silico-screened novel inhibitor against ascorbate peroxidase of Leishmania donovani. Antimicrob Agents Chemother 64:e01766-19. https://doi.org/10.1128/AAC.01766-19.

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Leishmanicidal Activity of an In Silico-Screened Novel Inhibitor against Ascorbate Peroxidase of Leishmania donovani
Mohammad Kashif, Ankush Paladhi, Ranjeet Singh, Sankar Bhattacharyya, Sumit Kumar Hira, Partha Pratim Manna
Antimicrobial Agents and Chemotherapy Jun 2020, 64 (7) e01766-19; DOI: 10.1128/AAC.01766-19

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Leishmanicidal Activity of an In Silico-Screened Novel Inhibitor against Ascorbate Peroxidase of Leishmania donovani
Mohammad Kashif, Ankush Paladhi, Ranjeet Singh, Sankar Bhattacharyya, Sumit Kumar Hira, Partha Pratim Manna
Antimicrobial Agents and Chemotherapy Jun 2020, 64 (7) e01766-19; DOI: 10.1128/AAC.01766-19
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KEYWORDS

in silico
molecular dynamics
ML-240
Leishmania
ascorbate peroxidase
miltefosine
oxidative stress

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