DOI: 10.1128/AAC.00321-20
ABSTRACT
KPC-50 is a KPC-3 variant identified from a Klebsiella pneumoniae clinical isolate recovered in Switzerland in 2019. Compared to KPC-3, KPC-50 shows (i) a three-amino-acid insertion (Glu-Ala-Val) between amino acids 276 and 277, (ii) an increased affinity to ceftazidime, (iii) a decreased sensitivity to avibactam, explaining the ceftazidime-avibactam resistance, and (iv) an association with a sharp reduction of its carbapenemase activity.
FOOTNOTES
- Received 18 February 2020.
- Returned for modification 26 March 2020.
- Accepted 13 May 2020.
- Accepted manuscript posted online 26 May 2020.
Supplemental material is available online only.
- Copyright © 2020 American Society for Microbiology.
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