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Letter to the Editor

Reduced Susceptibility to Carbapenems in a Klebsiella pneumoniae Clinical Isolate Producing SCO-1 and CTX-M-15 β-Lactamases Together with OmpK35 and OmpK36 Porin Deficiency

Carolina Venditti, Ornella Butera, Anna Proia, Luigi Rigacci, Bruno Mariani, Gabriella Parisi, Francesco Messina, Alessandro Capone, Carla Nisii, Antonino Di Caro
Carolina Venditti
aLaboratory of Microbiology, National Institute for Infectious Diseases L. Spallanzani, IRCCS, Rome, Italy
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Ornella Butera
aLaboratory of Microbiology, National Institute for Infectious Diseases L. Spallanzani, IRCCS, Rome, Italy
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Anna Proia
bHaematology and Haematopoietic Stem Cells Transplant Unit, San Camillo-Forlanini Hospital, Rome, Italy
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Luigi Rigacci
bHaematology and Haematopoietic Stem Cells Transplant Unit, San Camillo-Forlanini Hospital, Rome, Italy
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Bruno Mariani
cLaboratory of Microbiology and Virology, San Camillo Forlanini Hospital, Rome, Italy
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Gabriella Parisi
cLaboratory of Microbiology and Virology, San Camillo Forlanini Hospital, Rome, Italy
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Francesco Messina
aLaboratory of Microbiology, National Institute for Infectious Diseases L. Spallanzani, IRCCS, Rome, Italy
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Alessandro Capone
dSevere and Immunocompromised-associated Infections Unit, National Institute for Infectious Diseases L. Spallanzani, IRCCS, Rome, Italy
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Carla Nisii
aLaboratory of Microbiology, National Institute for Infectious Diseases L. Spallanzani, IRCCS, Rome, Italy
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Antonino Di Caro
aLaboratory of Microbiology, National Institute for Infectious Diseases L. Spallanzani, IRCCS, Rome, Italy
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DOI: 10.1128/AAC.00556-20
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  • TABLE 1

    Phenotypic and molecular analysis of the K. pneumoniae clinical isolate described herea

    TABLE 1
    • ↵a AMK, amikacin; CAZ, ceftazidime; CIP, ciprofloxacin; ETP, ertapenem; MEM, meropenem; IPM, imipenem; GEN, gentamicin; TZP, piperacillin-tazobactam; SXT, trimethoprim-sulfamethoxazole; CST, colistin; TGC, tigecycline; CZA, ceftazidime-avibactam; CTL, cefotaxime-clavulanic acid; I-R, imipenem-relebactam; MVB, meropenem-vaborbactam; S, susceptible; R, resistant.

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Reduced Susceptibility to Carbapenems in a Klebsiella pneumoniae Clinical Isolate Producing SCO-1 and CTX-M-15 β-Lactamases Together with OmpK35 and OmpK36 Porin Deficiency
Carolina Venditti, Ornella Butera, Anna Proia, Luigi Rigacci, Bruno Mariani, Gabriella Parisi, Francesco Messina, Alessandro Capone, Carla Nisii, Antonino Di Caro
Antimicrobial Agents and Chemotherapy Jul 2020, 64 (8) e00556-20; DOI: 10.1128/AAC.00556-20

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Reduced Susceptibility to Carbapenems in a Klebsiella pneumoniae Clinical Isolate Producing SCO-1 and CTX-M-15 β-Lactamases Together with OmpK35 and OmpK36 Porin Deficiency
Carolina Venditti, Ornella Butera, Anna Proia, Luigi Rigacci, Bruno Mariani, Gabriella Parisi, Francesco Messina, Alessandro Capone, Carla Nisii, Antonino Di Caro
Antimicrobial Agents and Chemotherapy Jul 2020, 64 (8) e00556-20; DOI: 10.1128/AAC.00556-20
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KEYWORDS

ESBLs
Klebsiella pneumoniae
OmpK35
OmpK36
SCO-1
carbapenem resistance
porin deficiency

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