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Mechanisms of Resistance

Antimicrobial Susceptibility and Clonality of Vaginally Derived Multidrug-Resistant Mobiluncus Isolates in China

Xueying Zhang, Yongying Bai, Long Zhang, Mohamed S. Draz, Zhi Ruan, Yuning Zhu
Xueying Zhang
aDepartment of Clinical Laboratory, Branch of National Clinical Research Center for Obstetrics and Gynecology, Women’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
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Yongying Bai
aDepartment of Clinical Laboratory, Branch of National Clinical Research Center for Obstetrics and Gynecology, Women’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
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Long Zhang
aDepartment of Clinical Laboratory, Branch of National Clinical Research Center for Obstetrics and Gynecology, Women’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
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Mohamed S. Draz
bDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, USA
cWyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, Massachusetts, USA
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Zhi Ruan
dDepartment of Clinical Laboratory, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China
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Yuning Zhu
aDepartment of Clinical Laboratory, Branch of National Clinical Research Center for Obstetrics and Gynecology, Women’s Hospital, Zhejiang University School of Medicine, Hangzhou, China
eInstitute of Laboratory Medicine, Zhejiang University, Hangzhou, China
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DOI: 10.1128/AAC.00780-20
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    FIG 1

    Comparison of the homologous regions shared by clindamycin-resistant (I and II) and clindamycin-susceptible (III and IV) isolates. Arrows represent coding sequences [red arrows, erm(X); pink arrows, IS1249] and indicate the direction of transcription. The arrow size is proportional to the gene length.

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    FIG 2

    Recombination-filtered core genome phylogeny and the distribution of antimicrobial resistance genes for M. curtisii isolates. The cell in a different color indicates the presence of antimicrobial resistance genes, and the blank cell indicates the absence of the gene. Isolates sequenced in this study are in red.

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    FIG 3

    Recombination-filtered core genome phylogeny and the distribution of antimicrobial resistance genes for M. mulieris isolates. The cell in a different color indicates the presence of antimicrobial resistance genes, and the blank cell indicates the absence of the gene. Isolates sequenced in this study are in red.

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  • TABLE 1

    The MICs of six antimicrobial agents against 30 M. curtisii isolates and 33 M. mulieris isolates recovered from patients with bacterial vaginosis

    TABLE 1
    • ↵a R, resistance.

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Antimicrobial Susceptibility and Clonality of Vaginally Derived Multidrug-Resistant Mobiluncus Isolates in China
Xueying Zhang, Yongying Bai, Long Zhang, Mohamed S. Draz, Zhi Ruan, Yuning Zhu
Antimicrobial Agents and Chemotherapy Jul 2020, 64 (8) e00780-20; DOI: 10.1128/AAC.00780-20

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Antimicrobial Susceptibility and Clonality of Vaginally Derived Multidrug-Resistant Mobiluncus Isolates in China
Xueying Zhang, Yongying Bai, Long Zhang, Mohamed S. Draz, Zhi Ruan, Yuning Zhu
Antimicrobial Agents and Chemotherapy Jul 2020, 64 (8) e00780-20; DOI: 10.1128/AAC.00780-20
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KEYWORDS

Mobiluncus spp.
antimicrobial resistance
clindamycin
metronidazole
whole-genome sequencing

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