DOI: 10.1128/AAC.00859-20
Article Figures & Data
Figures
- FIG 1
Pharmacokinetic profiles of a single dose of amikacin. n = 4 rats per group. Data are shown as means ± SD.
- FIG 2
Time to onset of nephrotoxicity. n = 10 per group, P = 0.001.
- FIG 3
Amikacin (AMK) concentrations in renal tissues stratified by outcomes. n = 4 rats per group. Data are shown as means ± SD, P = 0.009.
Tables
- TABLE 1
Best-first parameter estimates for the single-dose pharmacokinetics study
↵a R2, coefficient of correlation; ka, absorption rate constant; ke1, elimination rat constant; t1/2, terminal elimination half-life; V, volume of distribution; AUC0→∞, area under the concentration-time curve from 0 h to infinity.
