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Screening Repurposing Libraries for Identification of Drugs with Novel Antifungal Activity

Gina Wall, Jose L. Lopez-Ribot
Gina Wall
aDepartment of Biology and The South Texas Center for Emerging Infectious Diseases, The University of Texas at San Antonio, San Antonio, Texas, USA
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Jose L. Lopez-Ribot
aDepartment of Biology and The South Texas Center for Emerging Infectious Diseases, The University of Texas at San Antonio, San Antonio, Texas, USA
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  • ORCID record for Jose L. Lopez-Ribot
DOI: 10.1128/AAC.00924-20
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ABSTRACT

Fungal organisms are ubiquitous in nature, and progress of modern medicine is creating an expanding number of severely compromised patients susceptible to a variety of opportunistic fungal infections. These infections are difficult to diagnose and treat, leading to high mortality rates. The limited antifungal arsenal, the toxicity of current antifungal drugs, the development of resistance, and the emergence of new multidrug-resistant fungi, all highlight the urgent need for new antifungal agents. Unfortunately, the development of a novel antifungal is a rather long and expensive proposition, and no new classes of antifungal agents have reached the market in the last 2 decades. Drug repurposing, or finding new indications for old drugs, represents a promising alternative pathway to drug development that is particularly appealing within the academic environment. In the last few years, there has been a growing interest in repurposing approaches in the antifungal arena, with multiple groups of investigators having performed screenings of different repurposing libraries against different pathogenic fungi in search for drugs with previously unrecognized antifungal effects. Overall, these repurposing efforts may lead to the fast deployment of drugs with novel antifungal activity, which can rapidly bring benefits to patients, while at the same time reducing health care costs.

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Screening Repurposing Libraries for Identification of Drugs with Novel Antifungal Activity
Gina Wall, Jose L. Lopez-Ribot
Antimicrobial Agents and Chemotherapy Aug 2020, 64 (9) e00924-20; DOI: 10.1128/AAC.00924-20

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Screening Repurposing Libraries for Identification of Drugs with Novel Antifungal Activity
Gina Wall, Jose L. Lopez-Ribot
Antimicrobial Agents and Chemotherapy Aug 2020, 64 (9) e00924-20; DOI: 10.1128/AAC.00924-20
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  • Top
  • Article
    • ABSTRACT
    • INTRODUCTION
    • FUNGI, FUNGAL INFECTIONS, AND CURRENT ANTIFUNGAL DRUGS
    • DRUG REPURPOSING VERSUS DE NOVO DRUG DISCOVERY
    • REPURPOSING FOR THE IDENTIFICATION OF DRUGS WITH NOVEL ANTIFUNGAL ACTIVITY
    • SCREENING REPURPOSING LIBRARIES TO IDENTIFY COMPOUNDS WITH PREVIOUSLY UNIDENTIFIED ANTIFUNGAL ACTIVITY
    • FUTURE DIRECTIONS AND CONCLUSIONS
    • ACKNOWLEDGMENTS
    • REFERENCES
  • Figures & Data
  • Info & Metrics
  • PDF

KEYWORDS

antifungal agents
antifungal drug development
drug repurposing
fungal infections
repositioning

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