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Chemistry; Biosynthesis

New Amides Containing Selenium as Potent Leishmanicidal Agents Targeting Trypanothione Reductase

Mikel Etxebeste-Mitxeltorena, Daniel Plano, Socorro Espuelas, Esther Moreno, Carlos Aydillo, Antonio Jiménez-Ruiz, Juan Carlos García Soriano, Carmen Sanmartín
Mikel Etxebeste-Mitxeltorena
aUniversidad de Navarra, Facultad de Farmacia y Nutrición, Departamento de Tecnología y Química Farmacéuticas, Irunlarrea, Pamplona, Spain
bInstituto de Salud Tropical, Universidad de Navarra, ISTUN, Irunlarrea, Pamplona, Spain
cInstituto de Investigaciones Sanitarias de Navarra (IdiSNA), Irunlarrea, Pamplona, Spain
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Daniel Plano
aUniversidad de Navarra, Facultad de Farmacia y Nutrición, Departamento de Tecnología y Química Farmacéuticas, Irunlarrea, Pamplona, Spain
bInstituto de Salud Tropical, Universidad de Navarra, ISTUN, Irunlarrea, Pamplona, Spain
cInstituto de Investigaciones Sanitarias de Navarra (IdiSNA), Irunlarrea, Pamplona, Spain
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Socorro Espuelas
aUniversidad de Navarra, Facultad de Farmacia y Nutrición, Departamento de Tecnología y Química Farmacéuticas, Irunlarrea, Pamplona, Spain
bInstituto de Salud Tropical, Universidad de Navarra, ISTUN, Irunlarrea, Pamplona, Spain
cInstituto de Investigaciones Sanitarias de Navarra (IdiSNA), Irunlarrea, Pamplona, Spain
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Esther Moreno
aUniversidad de Navarra, Facultad de Farmacia y Nutrición, Departamento de Tecnología y Química Farmacéuticas, Irunlarrea, Pamplona, Spain
bInstituto de Salud Tropical, Universidad de Navarra, ISTUN, Irunlarrea, Pamplona, Spain
cInstituto de Investigaciones Sanitarias de Navarra (IdiSNA), Irunlarrea, Pamplona, Spain
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Carlos Aydillo
aUniversidad de Navarra, Facultad de Farmacia y Nutrición, Departamento de Tecnología y Química Farmacéuticas, Irunlarrea, Pamplona, Spain
bInstituto de Salud Tropical, Universidad de Navarra, ISTUN, Irunlarrea, Pamplona, Spain
cInstituto de Investigaciones Sanitarias de Navarra (IdiSNA), Irunlarrea, Pamplona, Spain
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Antonio Jiménez-Ruiz
dDepartamento de Bioquímica y Biología Molecular, Universidad de Alcalá, Alcalá de Henares, Madrid, Spain
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Juan Carlos García Soriano
dDepartamento de Bioquímica y Biología Molecular, Universidad de Alcalá, Alcalá de Henares, Madrid, Spain
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Carmen Sanmartín
aUniversidad de Navarra, Facultad de Farmacia y Nutrición, Departamento de Tecnología y Química Farmacéuticas, Irunlarrea, Pamplona, Spain
bInstituto de Salud Tropical, Universidad de Navarra, ISTUN, Irunlarrea, Pamplona, Spain
cInstituto de Investigaciones Sanitarias de Navarra (IdiSNA), Irunlarrea, Pamplona, Spain
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  • ORCID record for Carmen Sanmartín
DOI: 10.1128/AAC.00524-20
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Article Information

DOI 
https://doi.org/10.1128/AAC.00524-20
PubMed 
33046492

Published By 
American Society for Microbiology Journals
History 
  • Received March 17, 2020
  • Returned for modification July 1, 2020
  • Accepted October 2, 2020
  • Published online December 16, 2020.

Copyright & Usage 
Copyright © 2020 American Society for Microbiology. All Rights Reserved.

Article Versions

  • Accepted Manuscript version (October 12, 2020).
  • You are viewing the most recent version of this article.

Author Information

  1. Mikel Etxebeste-Mitxeltorenaa,b,c,
  2. Daniel Planoa,b,c,
  3. Socorro Espuelasa,b,c,
  4. Esther Morenoa,b,c,
  5. Carlos Aydilloa,b,c,
  6. Antonio Jiménez-Ruizd,
  7. Juan Carlos García Sorianod and
  8. Carmen Sanmartína,b,c
  1. aUniversidad de Navarra, Facultad de Farmacia y Nutrición, Departamento de Tecnología y Química Farmacéuticas, Irunlarrea, Pamplona, Spain
  2. bInstituto de Salud Tropical, Universidad de Navarra, ISTUN, Irunlarrea, Pamplona, Spain
  3. cInstituto de Investigaciones Sanitarias de Navarra (IdiSNA), Irunlarrea, Pamplona, Spain
  4. dDepartamento de Bioquímica y Biología Molecular, Universidad de Alcalá, Alcalá de Henares, Madrid, Spain
  • Address correspondence to Carmen Sanmartín, sanmartin{at}unav.es.
  • Citation Etxebeste-Mitxeltorena M, Plano D, Espuelas S, Moreno E, Aydillo C, Jiménez-Ruiz A, Soriano JCG, Sanmartín C. 2021. New amides containing selenium as potent leishmanicidal agents targeting trypanothione reductase. Antimicrob Agents Chemother 65:e00524-20. https://doi.org/10.1128/AAC.00524-20.

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New Amides Containing Selenium as Potent Leishmanicidal Agents Targeting Trypanothione Reductase
Mikel Etxebeste-Mitxeltorena, Daniel Plano, Socorro Espuelas, Esther Moreno, Carlos Aydillo, Antonio Jiménez-Ruiz, Juan Carlos García Soriano, Carmen Sanmartín
Antimicrobial Agents and Chemotherapy Dec 2020, 65 (1) e00524-20; DOI: 10.1128/AAC.00524-20

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New Amides Containing Selenium as Potent Leishmanicidal Agents Targeting Trypanothione Reductase
Mikel Etxebeste-Mitxeltorena, Daniel Plano, Socorro Espuelas, Esther Moreno, Carlos Aydillo, Antonio Jiménez-Ruiz, Juan Carlos García Soriano, Carmen Sanmartín
Antimicrobial Agents and Chemotherapy Dec 2020, 65 (1) e00524-20; DOI: 10.1128/AAC.00524-20
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KEYWORDS

Amides
diselenide
selenocyanate
thiols
trypanothione reductase

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