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Mechanisms of Resistance

Identification and Characterization of a Novel FosA7 Member from Fosfomycin-Resistant Escherichia coli Clinical Isolates from Canadian Hospitals

Kieran A. Milner, Denice C. Bay, David Alexander, Andrew Walkty, James A. Karlowsky, Michael R. Mulvey, Meenu K. Sharma, George G. Zhanel
Kieran A. Milner
aDepartment of Medical Microbiology and Infectious Diseases, Max Rady College of Medicine, University of Manitoba, Winnipeg, Canada
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Denice C. Bay
aDepartment of Medical Microbiology and Infectious Diseases, Max Rady College of Medicine, University of Manitoba, Winnipeg, Canada
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  • ORCID record for Denice C. Bay
David Alexander
aDepartment of Medical Microbiology and Infectious Diseases, Max Rady College of Medicine, University of Manitoba, Winnipeg, Canada
bCadham Provincial Laboratory, Winnipeg, Canada
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Andrew Walkty
aDepartment of Medical Microbiology and Infectious Diseases, Max Rady College of Medicine, University of Manitoba, Winnipeg, Canada
cShared Health, Winnipeg, Canada
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James A. Karlowsky
aDepartment of Medical Microbiology and Infectious Diseases, Max Rady College of Medicine, University of Manitoba, Winnipeg, Canada
cShared Health, Winnipeg, Canada
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Michael R. Mulvey
aDepartment of Medical Microbiology and Infectious Diseases, Max Rady College of Medicine, University of Manitoba, Winnipeg, Canada
dPublic Health Agency of Canada–National Microbiology Laboratory, Winnipeg, Canada
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Meenu K. Sharma
aDepartment of Medical Microbiology and Infectious Diseases, Max Rady College of Medicine, University of Manitoba, Winnipeg, Canada
dPublic Health Agency of Canada–National Microbiology Laboratory, Winnipeg, Canada
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George G. Zhanel
aDepartment of Medical Microbiology and Infectious Diseases, Max Rady College of Medicine, University of Manitoba, Winnipeg, Canada
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DOI: 10.1128/AAC.00865-20
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ABSTRACT

Here, we characterize the fosA genes from three Escherichia coli clinical isolates recovered from Canadian patients. Each fosA sequence was individually overexpressed in E. coli BW25113, and antimicrobial susceptibility testing was performed to assess their role in fosfomycin resistance. The findings from this study identify and functionally characterize FosA3, FosA8, and novel FosA7 members and highlight the importance of phenotypic characterization of fosA genes.

FOOTNOTES

    • Received 1 May 2020.
    • Returned for modification 22 May 2020.
    • Accepted 16 October 2020.
    • Accepted manuscript posted online 19 October 2020.
  • Supplemental material is available online only.

  • Copyright © 2020 American Society for Microbiology.

All Rights Reserved.

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Identification and Characterization of a Novel FosA7 Member from Fosfomycin-Resistant Escherichia coli Clinical Isolates from Canadian Hospitals
Kieran A. Milner, Denice C. Bay, David Alexander, Andrew Walkty, James A. Karlowsky, Michael R. Mulvey, Meenu K. Sharma, George G. Zhanel
Antimicrobial Agents and Chemotherapy Dec 2020, 65 (1) e00865-20; DOI: 10.1128/AAC.00865-20

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Identification and Characterization of a Novel FosA7 Member from Fosfomycin-Resistant Escherichia coli Clinical Isolates from Canadian Hospitals
Kieran A. Milner, Denice C. Bay, David Alexander, Andrew Walkty, James A. Karlowsky, Michael R. Mulvey, Meenu K. Sharma, George G. Zhanel
Antimicrobial Agents and Chemotherapy Dec 2020, 65 (1) e00865-20; DOI: 10.1128/AAC.00865-20
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KEYWORDS

fosfomycin
fosA7
beta-lactamase
Escherichia coli
novel fosA

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