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Mechanisms of Action: Physiological Effects

Inhibition of PfMYST Histone Acetyltransferase Activity Blocks Plasmodium falciparum Growth and Survival

Utsav Sen, Akshaykumar Nayak, Juhi Khurana, Deepu Sharma, Ashish Gupta
Utsav Sen
aEpigenetics and Human Disease Laboratory, Department of Life Sciences, Shiv Nadar University, Gautam Budh Nagar, Uttar Pradesh, India
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Akshaykumar Nayak
aEpigenetics and Human Disease Laboratory, Department of Life Sciences, Shiv Nadar University, Gautam Budh Nagar, Uttar Pradesh, India
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Juhi Khurana
aEpigenetics and Human Disease Laboratory, Department of Life Sciences, Shiv Nadar University, Gautam Budh Nagar, Uttar Pradesh, India
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Deepu Sharma
aEpigenetics and Human Disease Laboratory, Department of Life Sciences, Shiv Nadar University, Gautam Budh Nagar, Uttar Pradesh, India
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Ashish Gupta
aEpigenetics and Human Disease Laboratory, Department of Life Sciences, Shiv Nadar University, Gautam Budh Nagar, Uttar Pradesh, India
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DOI: 10.1128/AAC.00953-20
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Article Information

DOI 
https://doi.org/10.1128/AAC.00953-20
PubMed 
33046499

Published By 
American Society for Microbiology Journals
History 
  • Received May 11, 2020
  • Returned for modification June 19, 2020
  • Accepted October 1, 2020
  • Published online December 16, 2020.

Copyright & Usage 
Copyright © 2020 American Society for Microbiology. All Rights Reserved.

Article Versions

  • Accepted Manuscript version (October 12, 2020).
  • You are viewing the most recent version of this article.

Author Information

  1. Utsav Sena,
  2. Akshaykumar Nayaka,
  3. Juhi Khuranaa,
  4. Deepu Sharmaa and
  5. Ashish Guptaa
  1. aEpigenetics and Human Disease Laboratory, Department of Life Sciences, Shiv Nadar University, Gautam Budh Nagar, Uttar Pradesh, India
  • Address correspondence to Ashish Gupta, ag315{at}snu.edu.in.
  • Utsav Sen and Akshaykumar Nayak are co-first authors and contributed equally to this work. Author order was determined on the basis of seniority.

  • Citation Sen U, Nayak A, Khurana J, Sharma D, Gupta A. 2021. Inhibition of PfMYST histone acetyltransferase activity blocks Plasmodium falciparum growth and survival. Antimicrob Agents Chemother 65:e00953-20. https://doi.org/10.1128/AAC.00953-20.

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Inhibition of PfMYST Histone Acetyltransferase Activity Blocks Plasmodium falciparum Growth and Survival
Utsav Sen, Akshaykumar Nayak, Juhi Khurana, Deepu Sharma, Ashish Gupta
Antimicrobial Agents and Chemotherapy Dec 2020, 65 (1) e00953-20; DOI: 10.1128/AAC.00953-20

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Inhibition of PfMYST Histone Acetyltransferase Activity Blocks Plasmodium falciparum Growth and Survival
Utsav Sen, Akshaykumar Nayak, Juhi Khurana, Deepu Sharma, Ashish Gupta
Antimicrobial Agents and Chemotherapy Dec 2020, 65 (1) e00953-20; DOI: 10.1128/AAC.00953-20
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KEYWORDS

Plasmodium
PfMYST
NU9056
TIP60
HAT assay
Plasmodium falciparum
malaria

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