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Epidemiology and Surveillance

Escherichia coli Sequence Type 457 Is an Emerging Extended-Spectrum-β-Lactam-Resistant Lineage with Reservoirs in Wildlife and Food-Producing Animals

Kristina Nesporova, Ethan R. Wyrsch, Adam Valcek, Ibrahim Bitar, Khin Chaw, Patrick Harris, Jaroslav Hrabak, Ivan Literak, Steven P. Djordjevic, Monika Dolejska
Kristina Nesporova
aCEITEC VFU Brno, University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic
bDepartment of Biology and Wildlife Diseases, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic
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Ethan R. Wyrsch
cThe ithree institute, University of Technology Sydney, Sydney, New South Wales, Australia
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Adam Valcek
aCEITEC VFU Brno, University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic
bDepartment of Biology and Wildlife Diseases, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic
dFaculty of Medicine, Biomedical Center, Charles University, Pilsen, Czech Republic
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Ibrahim Bitar
aCEITEC VFU Brno, University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic
dFaculty of Medicine, Biomedical Center, Charles University, Pilsen, Czech Republic
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Khin Chaw
eFaculty of Medicine, University of Queensland, UQ Centre for Clinical Research, Brisbane, Australia
fPathology Queensland, Brisbane, Australia
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Patrick Harris
eFaculty of Medicine, University of Queensland, UQ Centre for Clinical Research, Brisbane, Australia
fPathology Queensland, Brisbane, Australia
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Jaroslav Hrabak
dFaculty of Medicine, Biomedical Center, Charles University, Pilsen, Czech Republic
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Ivan Literak
aCEITEC VFU Brno, University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic
bDepartment of Biology and Wildlife Diseases, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic
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Steven P. Djordjevic
cThe ithree institute, University of Technology Sydney, Sydney, New South Wales, Australia
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Monika Dolejska
aCEITEC VFU Brno, University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic
bDepartment of Biology and Wildlife Diseases, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic
dFaculty of Medicine, Biomedical Center, Charles University, Pilsen, Czech Republic
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  • ORCID record for Monika Dolejska
DOI: 10.1128/AAC.01118-20
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ABSTRACT

Silver gulls carry phylogenetically diverse Escherichia coli, including globally dominant extraintestinal pathogenic E. coli (ExPEC) sequence types and pandemic ExPEC-ST131 clades; however, our large-scale study (504 samples) on silver gulls nesting off the coast of New South Wales identified E. coli ST457 as the most prevalent. A phylogenetic analysis of whole-genome sequences (WGS) of 138 ST457 samples comprising 42 from gulls, 2 from humans (Australia), and 14 from poultry farmed in Paraguay were compared with 80 WGS deposited in public databases from diverse sources and countries. E. coli ST457 strains are phylogenetic group F, carry fimH145, and partition into five main clades in accordance to predominant flagella H-antigen carriage. Although we identified considerable phylogenetic diversity among the 138 ST457 strains, closely related subclades (<100 SNPs) suggested zoonotic or zooanthroponosis transmission between humans, wild birds, and food-producing animals. Australian human clinical and gull strains in two of the clades were closely related (≤80 SNPs). Regarding plasmid content, country, or country/source, specific connections were observed, including I1/ST23, I1/ST314, and I1/ST315 disseminating blaCMY-2 in Australia, I1/ST113 carrying blaCTX-M-8 and mcr-5 in Paraguayan poultry, and F2:A-:B1 plasmids of Dutch origin being detected across multiple ST457 clades. We identified a high prevalence of nearly identical I1/ST23 plasmids carrying blaCMY-2 among Australian gull and clinical human strains. In summary, ST457 is a broad host range, geographically diverse E. coli lineage that can cause human extraintestinal disease, including urinary tract infection, and displays a remarkable ability to capture mobile elements that carry and transmit genes encoding resistance to critically important antibiotics.

FOOTNOTES

    • Received 2 June 2020.
    • Returned for modification 10 July 2020.
    • Accepted 18 September 2020.
    • Accepted manuscript posted online 5 October 2020.
  • Supplemental material is available online only.

  • Copyright © 2020 American Society for Microbiology.

All Rights Reserved.

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Escherichia coli Sequence Type 457 Is an Emerging Extended-Spectrum-β-Lactam-Resistant Lineage with Reservoirs in Wildlife and Food-Producing Animals
Kristina Nesporova, Ethan R. Wyrsch, Adam Valcek, Ibrahim Bitar, Khin Chaw, Patrick Harris, Jaroslav Hrabak, Ivan Literak, Steven P. Djordjevic, Monika Dolejska
Antimicrobial Agents and Chemotherapy Dec 2020, 65 (1) e01118-20; DOI: 10.1128/AAC.01118-20

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Escherichia coli Sequence Type 457 Is an Emerging Extended-Spectrum-β-Lactam-Resistant Lineage with Reservoirs in Wildlife and Food-Producing Animals
Kristina Nesporova, Ethan R. Wyrsch, Adam Valcek, Ibrahim Bitar, Khin Chaw, Patrick Harris, Jaroslav Hrabak, Ivan Literak, Steven P. Djordjevic, Monika Dolejska
Antimicrobial Agents and Chemotherapy Dec 2020, 65 (1) e01118-20; DOI: 10.1128/AAC.01118-20
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KEYWORDS

ST457
ExPEC
ESBL
AmpC
I1 plasmids

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