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Mechanisms of Resistance

Secretion of and Self-Resistance to the Novel Fibupeptide Antimicrobial Lugdunin by Distinct ABC Transporters in Staphylococcus lugdunensis

Sophia Krauss, Alexander Zipperer, Sebastian Wirtz, Julian Saur, Martin C. Konnerth, Simon Heilbronner, Benjamin O. Torres Salazar, Stephanie Grond, Bernhard Krismer, Andreas Peschel
Sophia Krauss
aInterfaculty Institute of Microbiology and Infection Medicine, Infection Biology, University of Tübingen, Tübingen, Germany
bGerman Center for Infection Research (DZIF), Tübingen, Germany
cCluster of Excellence: EXC 2124: Controlling Microbes to Fight Infection, Tübingen, Germany
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Alexander Zipperer
aInterfaculty Institute of Microbiology and Infection Medicine, Infection Biology, University of Tübingen, Tübingen, Germany
bGerman Center for Infection Research (DZIF), Tübingen, Germany
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Sebastian Wirtz
cCluster of Excellence: EXC 2124: Controlling Microbes to Fight Infection, Tübingen, Germany
dInstitute of Organic Chemistry, University of Tübingen, Tübingen, Germany
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Julian Saur
cCluster of Excellence: EXC 2124: Controlling Microbes to Fight Infection, Tübingen, Germany
dInstitute of Organic Chemistry, University of Tübingen, Tübingen, Germany
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Martin C. Konnerth
cCluster of Excellence: EXC 2124: Controlling Microbes to Fight Infection, Tübingen, Germany
dInstitute of Organic Chemistry, University of Tübingen, Tübingen, Germany
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Simon Heilbronner
aInterfaculty Institute of Microbiology and Infection Medicine, Infection Biology, University of Tübingen, Tübingen, Germany
bGerman Center for Infection Research (DZIF), Tübingen, Germany
cCluster of Excellence: EXC 2124: Controlling Microbes to Fight Infection, Tübingen, Germany
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Benjamin O. Torres Salazar
aInterfaculty Institute of Microbiology and Infection Medicine, Infection Biology, University of Tübingen, Tübingen, Germany
bGerman Center for Infection Research (DZIF), Tübingen, Germany
cCluster of Excellence: EXC 2124: Controlling Microbes to Fight Infection, Tübingen, Germany
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Stephanie Grond
cCluster of Excellence: EXC 2124: Controlling Microbes to Fight Infection, Tübingen, Germany
dInstitute of Organic Chemistry, University of Tübingen, Tübingen, Germany
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Bernhard Krismer
aInterfaculty Institute of Microbiology and Infection Medicine, Infection Biology, University of Tübingen, Tübingen, Germany
bGerman Center for Infection Research (DZIF), Tübingen, Germany
cCluster of Excellence: EXC 2124: Controlling Microbes to Fight Infection, Tübingen, Germany
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Andreas Peschel
aInterfaculty Institute of Microbiology and Infection Medicine, Infection Biology, University of Tübingen, Tübingen, Germany
bGerman Center for Infection Research (DZIF), Tübingen, Germany
cCluster of Excellence: EXC 2124: Controlling Microbes to Fight Infection, Tübingen, Germany
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DOI: 10.1128/AAC.01734-20
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Article Information

DOI 
https://doi.org/10.1128/AAC.01734-20
PubMed 
33106269

Published By 
American Society for Microbiology Journals
History 
  • Received August 11, 2020
  • Returned for modification September 14, 2020
  • Accepted October 15, 2020
  • Published online December 16, 2020.

Copyright & Usage 
Copyright © 2020 Krauss et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

Article Versions

  • Accepted Manuscript version (October 26, 2020).
  • You are viewing the most recent version of this article.

Author Information

  1. Sophia Kraussa,b,c,
  2. Alexander Zipperera,b*,
  3. Sebastian Wirtzc,d,
  4. Julian Saurc,d,
  5. Martin C. Konnerthc,d*,
  6. Simon Heilbronnera,b,c,
  7. Benjamin O. Torres Salazara,b,c,
  8. Stephanie Grondc,d,
  9. Bernhard Krismera,b,c and
  10. Andreas Peschela,b,c
  1. aInterfaculty Institute of Microbiology and Infection Medicine, Infection Biology, University of Tübingen, Tübingen, Germany
  2. bGerman Center for Infection Research (DZIF), Tübingen, Germany
  3. cCluster of Excellence: EXC 2124: Controlling Microbes to Fight Infection, Tübingen, Germany
  4. dInstitute of Organic Chemistry, University of Tübingen, Tübingen, Germany
  • Address correspondence to Bernhard Krismer, b.krismer{at}uni-tuebingen.de.
  • ↵* Present address: Alexander Zipperer, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Roche Pharma Research & Early Development, Basel, Switzerland; Martin C. Konnerth, EMC Microcollections GmbH, Tübingen, Germany.

  • Sophia Krauss and Alexander Zipperer contributed equally to this work. Author order was determined on the basis of ongoing employment.

  • Citation Krauss S, Zipperer A, Wirtz S, Saur J, Konnerth MC, Heilbronner S, Torres Salazar BO, Grond S, Krismer B, Peschel A. 2021. Secretion of and self-resistance to the novel fibupeptide antimicrobial lugdunin by distinct ABC transporters in Staphylococcus lugdunensis. Antimicrob Agents Chemother 65:e01734-20. https://doi.org/10.1128/AAC.01734-20.

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Secretion of and Self-Resistance to the Novel Fibupeptide Antimicrobial Lugdunin by Distinct ABC Transporters in Staphylococcus lugdunensis
Sophia Krauss, Alexander Zipperer, Sebastian Wirtz, Julian Saur, Martin C. Konnerth, Simon Heilbronner, Benjamin O. Torres Salazar, Stephanie Grond, Bernhard Krismer, Andreas Peschel
Antimicrobial Agents and Chemotherapy Dec 2020, 65 (1) e01734-20; DOI: 10.1128/AAC.01734-20

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Secretion of and Self-Resistance to the Novel Fibupeptide Antimicrobial Lugdunin by Distinct ABC Transporters in Staphylococcus lugdunensis
Sophia Krauss, Alexander Zipperer, Sebastian Wirtz, Julian Saur, Martin C. Konnerth, Simon Heilbronner, Benjamin O. Torres Salazar, Stephanie Grond, Bernhard Krismer, Andreas Peschel
Antimicrobial Agents and Chemotherapy Dec 2020, 65 (1) e01734-20; DOI: 10.1128/AAC.01734-20
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KEYWORDS

ABC transporters
Staphylococcus
drug resistance mechanisms
natural antimicrobial products

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