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Antiviral Agents

Low Tenofovir Plasma Exposure in HIV Oral Pre-exposure Prophylaxis Recipients with Gastrointestinal Disorders

Andrea Calcagno, Ivano Dal Conte, Dario Cattaneo, Roberto Testi, Massimiliano Mistrangelo, Cristina Gervasoni, Amedeo de Nicolò, Stefano Bonora, Antonio D’Avolio, Giovanni Di Perri
Andrea Calcagno
aUnit of Infectious Diseases, Department of Medical Sciences, University of Turin, Turin, Italy
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  • ORCID record for Andrea Calcagno
Ivano Dal Conte
bSexual Health Centre, Department of Prevention, ASL Città di Torino, Turin, Italy
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Dario Cattaneo
cUnit of Clinical Pharmacology, ASST Fatebenefratelli Sacco University Hospital, Milan, Italy
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Roberto Testi
bSexual Health Centre, Department of Prevention, ASL Città di Torino, Turin, Italy
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Massimiliano Mistrangelo
dDepartment of Surgical Sciences, University of Turin, Turin, Italy
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Cristina Gervasoni
eDepartment of Infectious Diseases, ASST Fatebenefratelli Sacco University Hospital, Milan, Italy
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Amedeo de Nicolò
fLaboratory of Clinical Pharmacology and Pharmacogenetics, Department of Medical Sciences, University of Turin, Turin, Italy
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Stefano Bonora
aUnit of Infectious Diseases, Department of Medical Sciences, University of Turin, Turin, Italy
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Antonio D’Avolio
fLaboratory of Clinical Pharmacology and Pharmacogenetics, Department of Medical Sciences, University of Turin, Turin, Italy
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Giovanni Di Perri
aUnit of Infectious Diseases, Department of Medical Sciences, University of Turin, Turin, Italy
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DOI: 10.1128/AAC.01902-20
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ABSTRACT

Four pre-exposure prophylaxis (PrEP) users with gastrointestinal disorders (sleeve gastrectomy, terminal ileitis, celiac disease, or chronic diarrhea) and receiving oral tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) were included. Despite self-reported high adherence, trough plasma tenofovir concentrations (after supervised intake) were significantly lower in these patients than in PrEP recipients without gastrointestinal disorders (21 ± 9.1 versus 138 ± 85 ng/ml). PrEP users with gastrointestinal disorders may need increased TDF doses or alternative prophylactic measures.

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Low Tenofovir Plasma Exposure in HIV Oral Pre-exposure Prophylaxis Recipients with Gastrointestinal Disorders
Andrea Calcagno, Ivano Dal Conte, Dario Cattaneo, Roberto Testi, Massimiliano Mistrangelo, Cristina Gervasoni, Amedeo de Nicolò, Stefano Bonora, Antonio D’Avolio, Giovanni Di Perri
Antimicrobial Agents and Chemotherapy Dec 2020, 65 (1) e01902-20; DOI: 10.1128/AAC.01902-20

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Low Tenofovir Plasma Exposure in HIV Oral Pre-exposure Prophylaxis Recipients with Gastrointestinal Disorders
Andrea Calcagno, Ivano Dal Conte, Dario Cattaneo, Roberto Testi, Massimiliano Mistrangelo, Cristina Gervasoni, Amedeo de Nicolò, Stefano Bonora, Antonio D’Avolio, Giovanni Di Perri
Antimicrobial Agents and Chemotherapy Dec 2020, 65 (1) e01902-20; DOI: 10.1128/AAC.01902-20
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KEYWORDS

tenofovir disoproxil fumarate
malabsorption
sleeve gastrectomy
PrEP
HIV
absorption
gastrointestinal
pharmacokinetics
tenofovir

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