DOI: 10.1128/AAC.01712-20
ABSTRACT
Fosfomycin is a decades-old antibiotic, currently reused because of its activity against multidrug-resistant bacteria. Here, we used a combined in vitro/in silico approach to search for fosfomycin resistance determinants in 25 new bacterial species isolated from the human microbiota. Putative resistance genes were cloned into a susceptible Escherichia coli strain. MIC values increased from 1 μg/ml to 1,024 μg/ml. Here, we report a new family of potential chromosomal fosfomycin resistance genes, named fosM.
FOOTNOTES
- Received 11 August 2020.
- Returned for modification 11 September 2020.
- Accepted 5 November 2020.
- Accepted manuscript posted online 16 November 2020.
Supplemental material is available online only.
- Copyright © 2021 American Society for Microbiology.
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