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Editor's Pick Experimental Therapeutics

Recombinant Paraprobiotics as a New Paradigm for Treating Gastrointestinal Nematode Parasites of Humans

Hanchen Li, Ambily Abraham, David Gazzola, Yan Hu, Gillian Beamer, Kelly Flanagan, Ernesto Soto, Florentina Rus, Zeynep Mirza, Austin Draper, Sridhar Vakalapudi, Cheryl Stockman, Perry Bain, Joseph F. Urban Jr., Gary R. Ostroff, Raffi V. Aroian
Hanchen Li
aProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
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Ambily Abraham
aProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
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David Gazzola
aProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
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Yan Hu
aProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
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Gillian Beamer
bDepartment of Infectious Disease and Global Health, Tufts University, North Grafton, Massachusetts, USA
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Kelly Flanagan
aProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
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Ernesto Soto
aProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
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Florentina Rus
aProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
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Zeynep Mirza
aProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
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Austin Draper
cSynthetic Biomanufacturing Facility, Utah State University, Logan, Utah, USA
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Sridhar Vakalapudi
cSynthetic Biomanufacturing Facility, Utah State University, Logan, Utah, USA
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Cheryl Stockman
dCummings School of Veterinary Medicine at Tufts University, North Grafton, Massachusetts, USA
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Perry Bain
dCummings School of Veterinary Medicine at Tufts University, North Grafton, Massachusetts, USA
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Joseph F. Urban Jr.
eUnited States Department of Agriculture, Agricultural Research Service, Beltsville Human Nutrition Research Center, Diet, Genomics, Immunology Laboratory, Beltsville, Maryland, USA
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Gary R. Ostroff
aProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
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Raffi V. Aroian
aProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
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  • ORCID record for Raffi V. Aroian
DOI: 10.1128/AAC.01469-20
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Article Information

DOI 
https://doi.org/10.1128/AAC.01469-20
PubMed 
33318013

Published By 
American Society for Microbiology Journals
History 
  • Received July 10, 2020
  • Returned for modification October 21, 2020
  • Accepted December 8, 2020
  • Published online February 17, 2021.

Copyright & Usage 
Copyright © 2021 Li et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

Article Versions

  • Accepted Manuscript version (December 14, 2020).
  • You are viewing the most recent version of this article.

Author Information

  1. Hanchen Lia,
  2. Ambily Abrahama,
  3. David Gazzolaa,
  4. Yan Hua*,
  5. Gillian Beamerb,
  6. Kelly Flanagana,
  7. Ernesto Sotoa,
  8. Florentina Rusa,
  9. Zeynep Mirzaa,
  10. Austin Draperc,
  11. Sridhar Vakalapudic,
  12. Cheryl Stockmand,
  13. Perry Baind,
  14. Joseph F. Urban Jr.e,
  15. Gary R. Ostroffa and
  16. Raffi V. Aroiana
  1. aProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
  2. bDepartment of Infectious Disease and Global Health, Tufts University, North Grafton, Massachusetts, USA
  3. cSynthetic Biomanufacturing Facility, Utah State University, Logan, Utah, USA
  4. dCummings School of Veterinary Medicine at Tufts University, North Grafton, Massachusetts, USA
  5. eUnited States Department of Agriculture, Agricultural Research Service, Beltsville Human Nutrition Research Center, Diet, Genomics, Immunology Laboratory, Beltsville, Maryland, USA
  • Address correspondence to Gary R. Ostroff, gary.ostroff{at}umassmed.edu, or Raffi V. Aroian, raffi.aroian{at}umassmed.edu.
  • ↵* Present address: Yan Hu, Biology Department, Worcester State University, Worcester, Massachusetts, USA.

  • Hanchen Li, Ambily Abraham, and David Gazzola contributed equally to this article. Hanchen Li and David Gazzola ran all parasite assays; Ambily Abraham ran development of IBaCC. Order picked at random between these three.

  • Citation Li H, Abraham A, Gazzola D, Hu Y, Beamer G, Flanagan K, Soto E, Rus F, Mirza Z, Draper A, Vakalapudi S, Stockman C, Bain P, Urban JF, Jr, Ostroff GR, Aroian RV. 2021. Recombinant paraprobiotics as a new paradigm for treating gastrointestinal nematode parasites of humans. Antimicrob Agents Chemother 65:e01469-20. https://doi.org/10.1128/AAC.01469-20.

Article usage

Article usage: December 2020 to March 2021

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Feb 202121533981
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Recombinant Paraprobiotics as a New Paradigm for Treating Gastrointestinal Nematode Parasites of Humans
Hanchen Li, Ambily Abraham, David Gazzola, Yan Hu, Gillian Beamer, Kelly Flanagan, Ernesto Soto, Florentina Rus, Zeynep Mirza, Austin Draper, Sridhar Vakalapudi, Cheryl Stockman, Perry Bain, Joseph F. Urban Jr., Gary R. Ostroff, Raffi V. Aroian
Antimicrobial Agents and Chemotherapy Feb 2021, 65 (3) e01469-20; DOI: 10.1128/AAC.01469-20

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Recombinant Paraprobiotics as a New Paradigm for Treating Gastrointestinal Nematode Parasites of Humans
Hanchen Li, Ambily Abraham, David Gazzola, Yan Hu, Gillian Beamer, Kelly Flanagan, Ernesto Soto, Florentina Rus, Zeynep Mirza, Austin Draper, Sridhar Vakalapudi, Cheryl Stockman, Perry Bain, Joseph F. Urban Jr., Gary R. Ostroff, Raffi V. Aroian
Antimicrobial Agents and Chemotherapy Feb 2021, 65 (3) e01469-20; DOI: 10.1128/AAC.01469-20
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KEYWORDS

Bacillus thuringiensis
anthelmintic
crystal protein
gastrointestinal nematodes
helminths
hookworms
paraprobiotic
soil-transmitted helminths

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