DOI: 10.1128/AAC.02215-20
ABSTRACT
Mycobacterium abscessus exhibits Arr (ADP-ribosyltransferase)-dependent rifampin resistance. In apparent contrast, rifabutin (RBT) has demonstrated promising activity in M. abscessus infection models, implying that RBT might not be inactivated by Arr. RBT susceptibility testing of M. abscessus Δarr revealed a strongly decreased MIC. Our findings suggest that the efficacy of RBT might be enhanced by rendering RBT resilient to Arr-dependent modification or by blocking M. abscessus Arr activity.
FOOTNOTES
- Received 19 October 2020.
- Returned for modification 10 November 2020.
- Accepted 3 December 2020.
- Accepted manuscript posted online 14 December 2020.
Supplemental material is available online only.
- Copyright © 2021 American Society for Microbiology.
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