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Experimental Therapeutics

A Hyaluronic Acid Hydrogel Loaded with Gentamicin and Vancomycin Successfully Eradicates Chronic Methicillin-Resistant Staphylococcus aureus Orthopedic Infection in a Sheep Model

Willemijn Boot, Tanja Schmid, Matteo D’Este, Olivier Guillaume, Andrew Foster, Laurent Decosterd, Robert G. Richards, David Eglin, Stephan Zeiter, Thomas F. Moriarty
Willemijn Boot
aAO Research Institute Davos, Davos Platz, Switzerland
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Tanja Schmid
aAO Research Institute Davos, Davos Platz, Switzerland
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Matteo D’Este
aAO Research Institute Davos, Davos Platz, Switzerland
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Olivier Guillaume
aAO Research Institute Davos, Davos Platz, Switzerland
c3D Printing and Biofabrication Group, Institute of Materials Science and Technology, TU Wien, Vienna, Austria
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Andrew Foster
aAO Research Institute Davos, Davos Platz, Switzerland
dDepartment of Orthopaedic Surgery and Jamieson Trauma Institute, Royal Brisbane and Women's Hospital, Queensland University of Technology, Brisbane, Australia
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Laurent Decosterd
bFaculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland
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Robert G. Richards
aAO Research Institute Davos, Davos Platz, Switzerland
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David Eglin
aAO Research Institute Davos, Davos Platz, Switzerland
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Stephan Zeiter
aAO Research Institute Davos, Davos Platz, Switzerland
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Thomas F. Moriarty
aAO Research Institute Davos, Davos Platz, Switzerland
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DOI: 10.1128/AAC.01840-20
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Article Information

DOI 
https://doi.org/10.1128/AAC.01840-20
PubMed 
33526492

Published By 
American Society for Microbiology Journals
History 
  • Received August 26, 2020
  • Returned for modification November 29, 2020
  • Accepted January 18, 2021
  • Published online March 18, 2021.

Copyright & Usage 
Copyright © 2021 American Society for Microbiology. All Rights Reserved.

Article Versions

  • Accepted Manuscript version (February 01, 2021).
  • You are viewing the most recent version of this article.

Author Information

  1. Willemijn Boota,
  2. Tanja Schmida,
  3. Matteo D’Estea,
  4. Olivier Guillaumea,c,
  5. Andrew Fostera,d,
  6. Laurent Decosterdb,
  7. Robert G. Richardsa,
  8. David Eglina,
  9. Stephan Zeitera and
  10. Thomas F. Moriartya
  1. aAO Research Institute Davos, Davos Platz, Switzerland
  2. bFaculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland
  3. c3D Printing and Biofabrication Group, Institute of Materials Science and Technology, TU Wien, Vienna, Austria
  4. dDepartment of Orthopaedic Surgery and Jamieson Trauma Institute, Royal Brisbane and Women's Hospital, Queensland University of Technology, Brisbane, Australia
  • Address correspondence to Thomas F. Moriarty, fintan.moriarty{at}aofoundation.org.
  • Citation Boot W, Schmid T, D’Este M, Guillaume O, Foster A, Decosterd L, Richards RG, Eglin D, Zeiter S, Moriarty TF. 2021. A hyaluronic acid hydrogel loaded with gentamicin and vancomycin successfully eradicates chronic methicillin-resistant Staphylococcus aureus orthopedic infection in a sheep model. Antimicrob Agents Chemother 65:e01840-20. https://doi.org/10.1128/AAC.01840-20.

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A Hyaluronic Acid Hydrogel Loaded with Gentamicin and Vancomycin Successfully Eradicates Chronic Methicillin-Resistant Staphylococcus aureus Orthopedic Infection in a Sheep Model
Willemijn Boot, Tanja Schmid, Matteo D’Este, Olivier Guillaume, Andrew Foster, Laurent Decosterd, Robert G. Richards, David Eglin, Stephan Zeiter, Thomas F. Moriarty
Antimicrobial Agents and Chemotherapy Mar 2021, 65 (4) e01840-20; DOI: 10.1128/AAC.01840-20

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A Hyaluronic Acid Hydrogel Loaded with Gentamicin and Vancomycin Successfully Eradicates Chronic Methicillin-Resistant Staphylococcus aureus Orthopedic Infection in a Sheep Model
Willemijn Boot, Tanja Schmid, Matteo D’Este, Olivier Guillaume, Andrew Foster, Laurent Decosterd, Robert G. Richards, David Eglin, Stephan Zeiter, Thomas F. Moriarty
Antimicrobial Agents and Chemotherapy Mar 2021, 65 (4) e01840-20; DOI: 10.1128/AAC.01840-20
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KEYWORDS

MRSA
biofilms
gentamicin
implanted devices
local delivery
osteomyelitis
vancomycin

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