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Susceptibility

Assessment of Piperacillin-Tazobactam-Meropenem Synergy against Serine Carbapenemase-Producing Enterobacterales Using Time-Kill Assays

Alexander Lawandi, Gleice C. Leite, Matthew P. Cheng, Brigitte Lefebvre, Jean Longtin, Todd C. Lee
Alexander Lawandi
aDepartment of Critical Care Medicine, National Institutes of Health Clinical Center, Bethesda, Maryland, USA
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Gleice C. Leite
bResearch Institute, McGill University Health Centre, Montreal, Quebec, Canada
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Matthew P. Cheng
cDivision of Infectious Diseases, Department of Medicine, McGill University Health Centre, Montreal, Quebec, Canada
dDivision of Medical Microbiology, Department of Laboratory and Pathology Medicine, McGill University Health Centre, Montreal, Quebec, Canada
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Brigitte Lefebvre
eLaboratoire de santé publique du Québec, Sainte-Anne-de-Bellevue, Quebec, Canada
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Jean Longtin
eLaboratoire de santé publique du Québec, Sainte-Anne-de-Bellevue, Quebec, Canada
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Todd C. Lee
cDivision of Infectious Diseases, Department of Medicine, McGill University Health Centre, Montreal, Quebec, Canada
fClinical Practice Assessment Unit, Department of Medicine, McGill University, Montreal, Quebec, Canada
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DOI: 10.1128/AAC.02317-20
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ABSTRACT

Synergy between piperacillin-tazobactam and meropenem against KPC-producing Klebsiella pneumoniae was recently demonstrated. We sought to test the combination against a broader range of serine carbapenemase producers. We tested the combination against 10 KPC-producing Escherichia coli and 10 OXA-48 family-producing K. pneumoniae isolates. Antibiotic concentrations used are achievable in critically ill patients. The combination was synergistic against 7 of 10 KPC producers and 9 of 10 OXA-48 producers. There was no synergy detected in control isolates producing NDM-1.

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Assessment of Piperacillin-Tazobactam-Meropenem Synergy against Serine Carbapenemase-Producing Enterobacterales Using Time-Kill Assays
Alexander Lawandi, Gleice C. Leite, Matthew P. Cheng, Brigitte Lefebvre, Jean Longtin, Todd C. Lee
Antimicrobial Agents and Chemotherapy Mar 2021, 65 (4) e02317-20; DOI: 10.1128/AAC.02317-20

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Assessment of Piperacillin-Tazobactam-Meropenem Synergy against Serine Carbapenemase-Producing Enterobacterales Using Time-Kill Assays
Alexander Lawandi, Gleice C. Leite, Matthew P. Cheng, Brigitte Lefebvre, Jean Longtin, Todd C. Lee
Antimicrobial Agents and Chemotherapy Mar 2021, 65 (4) e02317-20; DOI: 10.1128/AAC.02317-20
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KEYWORDS

Enterobacterales
antimicrobial resistance
carbapenemase
meropenem
piperacillin-tazobactam
synergy
time-kill assay

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