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Epidemiology and Surveillance

Polyclonal Dissemination of NDM-1- and NDM-9-Producing Escherichia coli and Klebsiella pneumoniae in French Polynesia

Saoussen Oueslati, Cécile Emeraud, Victor Grosperrin, Marc Levy, Garance Cotellon, Elodie Creton, Lauraine Gauthier, Rémy A. Bonnin, Thierry Naas, Laurent Dortet
Saoussen Oueslati
bFaculty of Medicine, INSERM UMR 1184, RESIST Unit Paris-Saclay University, Le Kremlin-Bicêtre, France
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Cécile Emeraud
aBacteriology-Hygiene Unit, Assistance Publique/Hôpitaux de Paris, Bicêtre Hospital, Le Kremlin-Bicêtre, France
bFaculty of Medicine, INSERM UMR 1184, RESIST Unit Paris-Saclay University, Le Kremlin-Bicêtre, France
cAssociated French National Reference Center for Antibiotic Resistance: Carbapenemase-Producing Enterobacteriaceae, Le Kremlin-Bicêtre, France
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Victor Grosperrin
bFaculty of Medicine, INSERM UMR 1184, RESIST Unit Paris-Saclay University, Le Kremlin-Bicêtre, France
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Marc Levy
dBacteriology-Hygiene Unit, French Polynesia Hospital, Tahiti
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Garance Cotellon
cAssociated French National Reference Center for Antibiotic Resistance: Carbapenemase-Producing Enterobacteriaceae, Le Kremlin-Bicêtre, France
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Elodie Creton
cAssociated French National Reference Center for Antibiotic Resistance: Carbapenemase-Producing Enterobacteriaceae, Le Kremlin-Bicêtre, France
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Lauraine Gauthier
aBacteriology-Hygiene Unit, Assistance Publique/Hôpitaux de Paris, Bicêtre Hospital, Le Kremlin-Bicêtre, France
bFaculty of Medicine, INSERM UMR 1184, RESIST Unit Paris-Saclay University, Le Kremlin-Bicêtre, France
cAssociated French National Reference Center for Antibiotic Resistance: Carbapenemase-Producing Enterobacteriaceae, Le Kremlin-Bicêtre, France
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Rémy A. Bonnin
bFaculty of Medicine, INSERM UMR 1184, RESIST Unit Paris-Saclay University, Le Kremlin-Bicêtre, France
cAssociated French National Reference Center for Antibiotic Resistance: Carbapenemase-Producing Enterobacteriaceae, Le Kremlin-Bicêtre, France
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Thierry Naas
aBacteriology-Hygiene Unit, Assistance Publique/Hôpitaux de Paris, Bicêtre Hospital, Le Kremlin-Bicêtre, France
bFaculty of Medicine, INSERM UMR 1184, RESIST Unit Paris-Saclay University, Le Kremlin-Bicêtre, France
cAssociated French National Reference Center for Antibiotic Resistance: Carbapenemase-Producing Enterobacteriaceae, Le Kremlin-Bicêtre, France
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Laurent Dortet
aBacteriology-Hygiene Unit, Assistance Publique/Hôpitaux de Paris, Bicêtre Hospital, Le Kremlin-Bicêtre, France
bFaculty of Medicine, INSERM UMR 1184, RESIST Unit Paris-Saclay University, Le Kremlin-Bicêtre, France
cAssociated French National Reference Center for Antibiotic Resistance: Carbapenemase-Producing Enterobacteriaceae, Le Kremlin-Bicêtre, France
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DOI: 10.1128/AAC.02437-20
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ABSTRACT

The whole-genome sequencing analysis revealed a polyclonal dissemination of NDM-1 and NDM-9 variants in Escherichia coli (n = 20) and Klebsiella pneumoniae (n = 2) in Tahiti since 2015 via interspecies transfer of three different blaNDM-carrying plasmids (IncR, IncHI2, and IncF) and patient-to-patient cross-transmission. It highlights the potential risk of importation of NDM producers in France, where French Polynesia is not considered stricto sensu a foreign country from which repatriated patients have to be screened.

FOOTNOTES

    • Received 19 November 2020.
    • Returned for modification 18 December 2020.
    • Accepted 14 January 2021.
    • Accepted manuscript posted online 25 January 2021.
  • Supplemental material is available online only.

  • Copyright © 2021 American Society for Microbiology.

All Rights Reserved.

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Polyclonal Dissemination of NDM-1- and NDM-9-Producing Escherichia coli and Klebsiella pneumoniae in French Polynesia
Saoussen Oueslati, Cécile Emeraud, Victor Grosperrin, Marc Levy, Garance Cotellon, Elodie Creton, Lauraine Gauthier, Rémy A. Bonnin, Thierry Naas, Laurent Dortet
Antimicrobial Agents and Chemotherapy Mar 2021, 65 (4) e02437-20; DOI: 10.1128/AAC.02437-20

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Polyclonal Dissemination of NDM-1- and NDM-9-Producing Escherichia coli and Klebsiella pneumoniae in French Polynesia
Saoussen Oueslati, Cécile Emeraud, Victor Grosperrin, Marc Levy, Garance Cotellon, Elodie Creton, Lauraine Gauthier, Rémy A. Bonnin, Thierry Naas, Laurent Dortet
Antimicrobial Agents and Chemotherapy Mar 2021, 65 (4) e02437-20; DOI: 10.1128/AAC.02437-20
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KEYWORDS

NDM-1
NDM-9
epidemiology
Escherichia coli
Tahiti
NDM-1
whole-genome sequencing

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