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More articles from Minireview

  • Minireview
    The future of antifungal drug therapy: novel compounds and targets
    Caroline Mota Fernandes, Deveney Dasilva, Krupanandan Haranahalli, J. Brian McCarthy, John Mallamo, Iwao Ojima, Maurizio Del Poeta
  • Open Access
    Small-Molecule Inhibitors of Chikungunya Virus: Mechanisms of Action and Antiviral Drug Resistance
    Minireview
    Small-Molecule Inhibitors of Chikungunya Virus: Mechanisms of Action and Antiviral Drug Resistance

    Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that has spread to more than 60 countries worldwide. CHIKV infection leads to a febrile illness known as chikungunya fever (CHIKF), which is characterized by long-lasting and debilitating joint and muscle pain. CHIKV can cause large-scale epidemics with high attack rates, which substantiates the need for development of effective therapeutics suitable for outbreak containment...

    Kristina Kovacikova, Martijn J. van Hemert
  • <em>Achromobacter</em> Infections and Treatment Options
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    Achromobacter Infections and Treatment Options

    Achromobacter is a genus of nonfermenting Gram-negative bacteria under order Burkholderiales. Although primarily isolated from respiratory tract of people with cystic fibrosis, Achromobacter spp. can cause a broad range of infections in hosts with other underlying conditions. Their rare occurrence and ever-changing taxonomy hinder defining their clinical features, risk factors for acquisition and adverse...

    Burcu Isler, Timothy J. Kidd, Adam G. Stewart, Patrick Harris, David L. Paterson
  • Metallo-β-Lactamases: Structure, Function, Epidemiology, Treatment Options, and the Development Pipeline
    Minireview
    Metallo-β-Lactamases: Structure, Function, Epidemiology, Treatment Options, and the Development Pipeline

    Modern medicine is threatened by the global rise of antibiotic resistance, especially among Gram-negative bacteria. Metallo-β-lactamase (MBL) enzymes are a particular concern and are increasingly disseminated worldwide, though particularly in Asia. Many MBL producers have multiple further drug resistances, leaving few obvious treatment options. Nonetheless, and more encouragingly, MBLs may be less effective agents of carbapenem...

    Sara E. Boyd, David M. Livermore, David C. Hooper, William W. Hope
  • Emerging Antimicrobial-Resistant High-Risk <span class="named-content genus-species" id="named-content-1">Klebsiella pneumoniae</span> Clones ST307 and ST147
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    Emerging Antimicrobial-Resistant High-Risk Klebsiella pneumoniae Clones ST307 and ST147

    There is an enormous global public health burden due to antimicrobial-resistant (AMR) Klebsiella pneumoniae high-risk clones. K. pneumoniae ST307 and ST147 are recent additions to the family of successful clones in the species. Both clones likely emerged in Europe during the early to mid-1990s and,...

    Gisele Peirano, Liang Chen, Barry N. Kreiswirth, Johann D. D. Pitout
  • (p)ppGpp and Its Role in Bacterial Persistence: New Challenges
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    (p)ppGpp and Its Role in Bacterial Persistence: New Challenges

    Antibiotic failure not only is due to the development of resistance by pathogens but can also often be explained by persistence and tolerance. Persistence and tolerance can be included in the “persistent phenotype,” with high relevance for clinics. Two of the most important molecular mechanisms involved in tolerance and persistence are toxin-antitoxin (TA) modules and signaling via guanosine pentaphosphate/tetraphosphate [(p)ppGpp],...

    Olga Pacios, Lucia Blasco, Inés Bleriot, Laura Fernandez-Garcia, Antón Ambroa, María López, German Bou, Rafael Cantón, Rodolfo Garcia-Contreras, Thomas K. Wood, Maria Tomás
  • Open Access
    Povidone Iodine: Properties, Mechanisms of Action, and Role in Infection Control and <em>Staphylococcus aureus</em> Decolonization
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    Povidone Iodine: Properties, Mechanisms of Action, and Role in Infection Control and Staphylococcus aureus Decolonization

    Nasal decolonization is an integral part of the strategies used to control and prevent the spread of methicillin-resistant Staphylococcus aureus (MRSA) infections. The two most commonly used agents for decolonization are intranasal mupirocin 2% ointment and chlorhexidine wash, but the increasing emergence of resistance and treatment failure has underscored the need...

    Didier Lepelletier, Jean Yves Maillard, Bruno Pozzetto, Anne Simon
  • Screening Repurposing Libraries for Identification of Drugs with Novel Antifungal Activity
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    Screening Repurposing Libraries for Identification of Drugs with Novel Antifungal Activity

    Fungal organisms are ubiquitous in nature, and progress of modern medicine is creating an expanding number of severely compromised patients susceptible to a variety of opportunistic fungal infections. These infections are difficult to diagnose and treat, leading to high mortality rates. The limited antifungal arsenal, the toxicity of current antifungal drugs, the development of resistance, and the emergence of new multidrug-resistant...

    Gina Wall, Jose L. Lopez-Ribot
  • Cetylpyridinium Chloride: Mechanism of Action, Antimicrobial Efficacy in Biofilms, and Potential Risks of Resistance
    Minireview
    Cetylpyridinium Chloride: Mechanism of Action, Antimicrobial Efficacy in Biofilms, and Potential Risks of Resistance

    Antimicrobial resistance is a serious issue for public health care all over the world. While resistance toward antibiotics has attracted strong interest among researchers and the general public over the last 2 decades, the directly related problem of resistance toward antiseptics and biocides has been somewhat left untended. In the field of dentistry, antiseptics are routinely used in professional care, but they are also included in...

    Xiaojun Mao, David L. Auer, Wolfgang Buchalla, Karl-Anton Hiller, Tim Maisch, Elmar Hellwig, Ali Al-Ahmad, Fabian Cieplik
  • The Emerging Role of β-Lactams in the Treatment of Methicillin-Resistant <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span> Bloodstream Infections
    Editor's Pick Minireview
    The Emerging Role of β-Lactams in the Treatment of Methicillin-Resistant Staphylococcus aureus Bloodstream Infections

    Methicillin-resistant Staphylococcus aureus (MRSA) bloodstream infections (BSI) are associated with substantial morbidity and mortality. Monotherapy with first-line antimicrobials such as vancomycin (VAN; glycopeptide) and daptomycin (DAP; lipopeptide) are inadequate in some cases due to reduced antibiotic susceptibilities or therapeutic failure. In recent years, β-...

    Kyle C. Molina, Taylor Morrisette, Matthew A. Miller, Vanthida Huang, Douglas N. Fish

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