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Antiviral Agents

Surveillance of Influenza A resistance to polymerase complex inhibitors by whole genome analysis, 2016-17, 2017-18 and 2018-19 Seasons, Eastern Spain

Beatriz Mengual-Chuliá, Andrés Alonso-Cordero, Laura Cano, M. del Mar Mosquera, Patricia de Molina, Roser Vendrell, Mariana Reyes-Prieto, Mireia Jané, Nuria Torner, Ana Isabel Martínez, Jordi Vila, Javier Díez-Domingo, M. Ángeles Marcos, F. Xavier López-Labrador; on behalf of the Valencia Hospital Network for the Study of Influenza and Respiratory Viruses Disease (VAHNSI)
Beatriz Mengual-Chuliá
aVirology Laboratory, Genomics and Health Area, Centro Superior de Investigación en Salud Pública, FISABIO-Public Health, Generalitat Valenciana, Valencia, Spain
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Andrés Alonso-Cordero
aVirology Laboratory, Genomics and Health Area, Centro Superior de Investigación en Salud Pública, FISABIO-Public Health, Generalitat Valenciana, Valencia, Spain
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Laura Cano
aVirology Laboratory, Genomics and Health Area, Centro Superior de Investigación en Salud Pública, FISABIO-Public Health, Generalitat Valenciana, Valencia, Spain
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M. del Mar Mosquera
bMicrobiology Service, Center of Biomedical Diagnostics, Hospital Clínic, Universitat de Barcelona, Institute of Global Health, Barcelona, Spain
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Patricia de Molina
bMicrobiology Service, Center of Biomedical Diagnostics, Hospital Clínic, Universitat de Barcelona, Institute of Global Health, Barcelona, Spain
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Roser Vendrell
bMicrobiology Service, Center of Biomedical Diagnostics, Hospital Clínic, Universitat de Barcelona, Institute of Global Health, Barcelona, Spain
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Mariana Reyes-Prieto
cBioinformatics and Sequencing Service, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana, FISABIO-Public Health, Generalitat Valenciana, Valencia, Spain
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Mireia Jané
dPublic Health Agency of Catalonia, Barcelona, Spain
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Nuria Torner
dPublic Health Agency of Catalonia, Barcelona, Spain
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Ana Isabel Martínez
dPublic Health Agency of Catalonia, Barcelona, Spain
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Jordi Vila
bMicrobiology Service, Center of Biomedical Diagnostics, Hospital Clínic, Universitat de Barcelona, Institute of Global Health, Barcelona, Spain
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  • ORCID record for Jordi Vila
Javier Díez-Domingo
eVaccine Research Area, Centro Superior de Investigación en Salud Pública, FISABIO-Public Health, Generalitat Valenciana, Valencia, Spain
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M. Ángeles Marcos
bMicrobiology Service, Center of Biomedical Diagnostics, Hospital Clínic, Universitat de Barcelona, Institute of Global Health, Barcelona, Spain
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F. Xavier López-Labrador
aVirology Laboratory, Genomics and Health Area, Centro Superior de Investigación en Salud Pública, FISABIO-Public Health, Generalitat Valenciana, Valencia, Spain
fCIBERESP, Instituto de Salud Carlos III, Madrid, Spain
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  • For correspondence: F.Xavier.Lopez@uv.es
DOI: 10.1128/AAC.02718-20
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ABSTRACT

Molecular surveillance by whole genome sequencing was used to monitor the susceptibility of circulating Influenza A viruses to three polymerase complex inhibitors. A total of 12 resistance substitutions were found among 285 genomes analysed, but none associated with high levels of resistance. Natural resistance to these influenza A antivirals is currently uncommon.

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Surveillance of Influenza A resistance to polymerase complex inhibitors by whole genome analysis, 2016-17, 2017-18 and 2018-19 Seasons, Eastern Spain
Beatriz Mengual-Chuliá, Andrés Alonso-Cordero, Laura Cano, M. del Mar Mosquera, Patricia de Molina, Roser Vendrell, Mariana Reyes-Prieto, Mireia Jané, Nuria Torner, Ana Isabel Martínez, Jordi Vila, Javier Díez-Domingo, M. Ángeles Marcos, F. Xavier López-Labrador on behalf of the Valencia Hospital Network for the Study of Influenza and Respiratory Viruses Disease (VAHNSI)
Antimicrobial Agents and Chemotherapy Mar 2021, AAC.02718-20; DOI: 10.1128/AAC.02718-20

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Surveillance of Influenza A resistance to polymerase complex inhibitors by whole genome analysis, 2016-17, 2017-18 and 2018-19 Seasons, Eastern Spain
Beatriz Mengual-Chuliá, Andrés Alonso-Cordero, Laura Cano, M. del Mar Mosquera, Patricia de Molina, Roser Vendrell, Mariana Reyes-Prieto, Mireia Jané, Nuria Torner, Ana Isabel Martínez, Jordi Vila, Javier Díez-Domingo, M. Ángeles Marcos, F. Xavier López-Labrador on behalf of the Valencia Hospital Network for the Study of Influenza and Respiratory Viruses Disease (VAHNSI)
Antimicrobial Agents and Chemotherapy Mar 2021, AAC.02718-20; DOI: 10.1128/AAC.02718-20
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