PT - JOURNAL ARTICLE AU - Cynamon, M. H. AU - Klemens, S. P. AU - Sharpe, C. A. AU - Chase, S. TI - Activities of Several Novel Oxazolidinones against<em>Mycobacterium tuberculosis</em> in a Murine Model AID - 10.1128/AAC.43.5.1189 DP - 1999 May 01 TA - Antimicrobial Agents and Chemotherapy PG - 1189--1191 VI - 43 IP - 5 4099 - http://aac.asm.org/content/43/5/1189.short 4100 - http://aac.asm.org/content/43/5/1189.full SO - Antimicrob. Agents Chemother.1999 May 01; 43 AB - The activities of linezolid, eperezolid, and PNU-100480 were evaluated in a murine model of tuberculosis. Approximately 107 viable Mycobacterium tuberculosis ATCC 35801 organisms were given intravenously to 4-week-old outbred CD-1 mice. In the first study, treatment was started 1 day postinfection and was given by gavage for 4 weeks. Viable cell counts were determined from homogenates of spleens and lungs. PNU-100480 was as active as isoniazid. Linezolid was somewhat less active than PNU-100480 and isoniazid. Eperezolid had little activity in this model. In the next two studies, treatment was started 1 week postinfection. A dose-response study was performed with PNU-100480 and linezolid (both at 25, 50, and 100 mg/kg of body weight). PNU-100480 was more active than linezolid, and its efficacy increased with an escalation of the dose. Subsequently, the activity of PNU-100480 alone and in combination with rifampin or isoniazid was evaluated and was compared to that of isoniazid-rifampin. The activity of PNU-100480 was similar to that of isoniazid and/or rifampin in the various combinations tested. Further evaluation of these oxazolidinones in the murine test system would be useful prior to the development of clinical studies with humans.