PT  - JOURNAL ARTICLE
AU  - Cynamon, M. H.
AU  - Klemens, S. P.
AU  - Sharpe, C. A.
AU  - Chase, S.
TI  - Activities of Several Novel Oxazolidinones against<em>Mycobacterium tuberculosis</em> in a Murine Model
AID  - 10.1128/AAC.43.5.1189
DP  - 1999 May 01
TA  - Antimicrobial Agents and Chemotherapy
PG  - 1189--1191
VI  - 43
IP  - 5
4099  - http://aac.asm.org/content/43/5/1189.short
4100  - http://aac.asm.org/content/43/5/1189.full
SO  - Antimicrob. Agents Chemother.1999 May 01; 43
AB  - The activities of linezolid, eperezolid, and PNU-100480 were evaluated in a murine model of tuberculosis. Approximately 107 viable Mycobacterium tuberculosis ATCC 35801 organisms were given intravenously to 4-week-old outbred CD-1 mice. In the first study, treatment was started 1 day postinfection and was given by gavage for 4 weeks. Viable cell counts were determined from homogenates of spleens and lungs. PNU-100480 was as active as isoniazid. Linezolid was somewhat less active than PNU-100480 and isoniazid. Eperezolid had little activity in this model. In the next two studies, treatment was started 1 week postinfection. A dose-response study was performed with PNU-100480 and linezolid (both at 25, 50, and 100 mg/kg of body weight). PNU-100480 was more active than linezolid, and its efficacy increased with an escalation of the dose. Subsequently, the activity of PNU-100480 alone and in combination with rifampin or isoniazid was evaluated and was compared to that of isoniazid-rifampin. The activity of PNU-100480 was similar to that of isoniazid and/or rifampin in the various combinations tested. Further evaluation of these oxazolidinones in the murine test system would be useful prior to the development of clinical studies with humans.