RT Journal Article
SR Electronic
T1 Pharmacokinetic Profile of Meropenem, Administered at 500 Milligrams Every 8 Hours, in Plasma and Cantharidin-Induced Skin Blister Fluid
JF Antimicrobial Agents and Chemotherapy
JO Antimicrob. Agents Chemother.
FD American Society for Microbiology
SP 1771
OP 1773
DO 10.1128/AAC.47.5.1771-1773.2003
VO 47
IS 5
A1 Maglio, Dana
A1 Teng, Renli
A1 Thyrum, Per T.
A1 Nightingale, Charles H.
A1 Nicolau, David P.
YR 2003
UL http://aac.asm.org/content/47/5/1771.abstract
AB The pharmacokinetic disposition of meropenem, administered at 500 mg every 8 h, in plasma and cantharidin-induced blister fluid is described. Peak meropenem concentrations in blister fluid lagged behind peak meropenem concentrations in plasma, while a lower elimination rate from blister fluid was also noted. The mean penetration of meropenem into blister fluid was 67%. The pharmacokinetic profile of meropenem in blister fluid supports the utility of this dose in the management of skin and soft tissue infections.