PT - JOURNAL ARTICLE AU - Tanaka, Kaori AU - Mikamo, Hiroshige AU - Nakao, Ken'ichi AU - Watanabe, Kunitomo TI - In Vitro Antianaerobic Activity of DX-619, a New Des-Fluoro(6) Quinolone AID - 10.1128/AAC.00639-06 DP - 2006 Nov 01 TA - Antimicrobial Agents and Chemotherapy PG - 3908--3913 VI - 50 IP - 11 4099 - http://aac.asm.org/content/50/11/3908.short 4100 - http://aac.asm.org/content/50/11/3908.full SO - Antimicrob. Agents Chemother.2006 Nov 01; 50 AB - The in vitro activity of DX-619, a new des-F(6) quinolone, against anaerobic bacteria was evaluated. DX-619 showed potent activity against Bacteroides, Prevotella, Fusobacterium, Micromonas, Actinomyces, and Clostridium spp., with MIC50s/MIC90s of ≤0.03 to 0.25/≤0.03 to 1 μg/ml, respectively. DX-619 was also active against imipenem-resistant Bacteroides spp., with MIC50s/MIC90s of 0.25/1 μg/ml, respectively.