PT  - JOURNAL ARTICLE
AU  - Wolter, Daniel J.
AU  - Hanson, Nancy D.
AU  - Lister, Philip D.
TI  - AmpC and OprD Are Not Involved in the Mechanism of Imipenem Hypersusceptibility among <em>Pseudomonas aeruginosa</em> Isolates Overexpressing the <em>mexCD</em>-<em>oprJ</em> Efflux Pump
AID  - 10.1128/AAC.49.11.4763-4766.2005
DP  - 2005 Nov 01
TA  - Antimicrobial Agents and Chemotherapy
PG  - 4763--4766
VI  - 49
IP  - 11
4099  - http://aac.asm.org/content/49/11/4763.short
4100  - http://aac.asm.org/content/49/11/4763.full
SO  - Antimicrob. Agents Chemother.2005 Nov 01; 49
AB  - Pseudomonas aeruginosa strains that overexpress mexCD-oprJ become hypersusceptible to imipenem. Disruption of AmpC induction has been suggested to cause this phenotype. However, data from this study demonstrate that hypersusceptibility to imipenem can develop without changes in ampC expression or AmpC activity. Furthermore, hypersusceptibility is not caused by changes in expression of the outer membrane porin, OprD.