Table 2.

Mutations detected in isoniazid-susceptible and isoniazid-resistant isolates by molecular beacon assay

MutationNo. (%) of isolatesP
Madrid isolatesNew York isolates
Susceptible (n = 7)Resistant (n = 49)Susceptible (n = 48)Resistant (n = 45)
katG codon 315 alone15 (30.6)26 (57.8)<0.012
inhA ribosomal binding site alone21 (42.9)4 (8.8)<0.001
ahpC-oxyR intragenic region alone4 (8.2)2 (4.4)NSa
katG plusinhA1 (2)1 (2.2)NS
katG plusahpC-oxyR1 (2)1 (2.2)NS
inhA plusahpC-oxyR5 (10.2)NS
kasA codon 66NS
kasA codon 2695 (10.4)5 (11.1)NS
kasA codon 312NS
kasAcodon 413NS
No mutation detectedNAb3 (6.1)NA11 (24.4)0.02
  • a NS, not significant.

  • b NA, not applicable.