Table 2.

Effect of deletion of acrAB on susceptibility of FQ-resistant mutants of E. coli AG100 and AG112a

StrainMICa (μg/ml)
OFLCIPTVASPXTETCMLCFOX
+Δ+Δ+Δ+Δ+Δ+Δ+Δ
AG1000.03≤0.015≤0.015≤0.0150.06≤0.03≤0.015≤0.01510.54140.5
1-AG1000.250.060.250.060.250.060.125≤0.015214140.5
2-AG10010.060.50.060.250.060.25≤0.01520.5161160.5
3*-AG10020.0610.060.50.060.5≤0.01581321320.5
4*-AG10040.12520.12520.1252≤0.01581641321
AG1120.125≤0.0150.06≤0.0150.125≤0.030.06≤0.01541161321
1-AG11210.060.50.030.50.060.25≤0.01540.5321161
2-AG11240.0620.0310.061≤0.015161641320.5
3-AG11280.0640.0320.062≤0.01580.5641640.5
  • a Determined by the broth microdilution method according to the standards of the National Committee for Clinical Laboratory Standards (20). Results are representative of experiments done in duplicate. +, acrABpresent; Δ, acrAB was deleted.