Table 3.

Effects of SCH 56592 and benznidazole in a murine model of acute Chagas' disease with different strains ofT. cruzi

StrainNo. of negative mice/no. testeda
Control (untreated)Benznidazole, 100 mg/kg/daySCH 56592, 5 mg/kg/daySCH 56592, 10 mg/kg/daySCH 56592, 20 mg/kg/day
CL0/109/96/69/99/9
Y0/104/85/96/107/9
Colombiana0/103/65/94/96/8
SC-280/102/75/96/98/8
VL-100/101/72/43/105/9
  • a Female albino Swiss mice (18 to 20 g) were inoculated with 104 bloodstream trypomastigotes of the indicated strain, and treatment was started 4 days p.i. The drugs were given orally for 28 days, followed by a 7-day rest and another 15 days of treatment. Parasitological cure of animals which survived until the end of the observation period (113 days p.i.) was assessed by hemoculture, xenodiagnosis, and flow cytometry analysis for anti-liveT. cruzi antibodies. Animals were considered cured when all three tests were negative (for details see Materials and Methods).