Table 2.

Effects of SCH 56592 and benznidazole in a murine model of acute Chagas' disease with different strains ofT. cruzi

StrainNo. of survivors/total no. receivinga:
No drug (control)Benznidazole, 100 mg/kg/daySCH 56592, 5 mg/kg/daySCH 56592, 10 mg/kg/daySCH 56592, 20 mg/kg/day
CL0/109/106/109/109/10
Y0/108/109/1010/109/10
Colombiana0/106/109/109/108/10
SC-280/107/109/109/1010/10
VL-100/107/104/1010/109/10
  • a Female albino Swiss mice (18 to 20 g) were inoculated with 104 bloodstream trypomastigotes of the indicated strain, and treatment was started 4 days p.i. The drugs were given orally for 28 days, followed by a 7-day rest and another 15 days of treatment. Animals were monitored for 113 days p.i.